3-DEHYDROQUINATE SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1sg6(B) : NPTKISILGRESIIADFGLWRNYVAKDLISDCSSTTYVLVTDTNIGSIYT 
         :                                                    
 1dqs(B) : NPTKISILGRESIIADFGLWRNYVAKDLISDCSSTTYVLVTDTNIGSIYT 
           __________________________________________________ 

           __________________________________________________ 
 1sg6(B) : PSFEEAFRKRAAEITPSPRLLIYNRPPGEVSKSRQTKADIEDWMLSQNPP 
         :                                                    
 1dqs(B) : PSFEEAFRKRAAEITPSPRLLIYNRPPGEVSKSRQTKADIEDWMLSQNPP 
           __________________________________________________ 

           __________________________________________________ 
 1sg6(B) : CGRDTVVIALGGGVIGDLTGFVASTYMRGVRYVQVPTTLLAMVDSSIGGK 
         :                                                    
 1dqs(B) : CGRDTVVIALGGGVIGDLTGFVASTYMRGVRYVQVPTTLLAMVDSSIGGK 
           __________________________________________________ 

           _____________________________184__________________ 
 1sg6(B) : TAIDTPLGKNLIGAIWQPTKIYIDLEFLETLPVREFINGMAEVIKTAAIS 
         :                                                    
 1dqs(B) : TAIDTPLGKNLIGAIWQPTKIYIDLEFLETLPVREFINGMAEVIKTAAIS 
           _____________________________184__________________ 

           __________________________________________________ 
 1sg6(B) : SEEEFTALEENAETILKAVRREVTPGEHRFEGTEEILKARILASARHKAY 
         :                                                    
 1dqs(B) : SEEEFTALEENAETILKAVRR-----------tEEILKARILASARHKAY 
           __________________________________________________ 

           __________________________________________________ 
 1sg6(B) : VVSA----gGLRNLLNWGHSIGHAIEAILTPQILHGECVAIGMVKEAELA 
         :                                                    
 1dqs(B) : VVSADEREGGLRNLLNWGHSIGHAIEAILTPQILHGECVAIGMVKEAELA 
           __________________________________________________ 

           __________________________________________________ 
 1sg6(B) : RHLGILKGVAVSRIVKCLAAYGLPTSLKDARIRKLTAGKHCSVDQLMFNM 
         :                                                    
 1dqs(B) : RHLGILKGVAVSRIVKCLAAYGLPTSLKDARIRKLTAGKHCSVDQLMFNM 
           __________________________________________________ 

           _________________________________________          
 1sg6(B) : AL--------kKIVLLSAIGTPYETRASVVANEDIRVVLA*          
         :                                                    
 1dqs(B) : ALDKKNDGPKKKIVLLSAIGTPYETRASVVANEDIRVVLAP          
           _________________________________________          

Details

  Property   Value
 Conformer 1 1sg6(B)
 Conformer 2 1dqs(B)
 Radius gyration for conformer 1 21.23 A
 Radius gyration for conformer 2 20.63 A
 EC Number 4.2.3.4   4.6.1.3  
Click here to see the DynDom results or the famliy
 Trigger ligands CRB401
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG264  ASN162  ASN268  ASP146  GLU194  HIS271  HIS275  HIS287  LEU267  LYS152  LYS197  LYS250  LYS356 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT