Sarcoplasmic/endoplasmic reticulum calcium AT
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1wpg(C) : MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLW 
         :                                                    
 2eau(A) : MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLW 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIA 
         :                                                    
 2eau(A) : ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIA 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : NAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDI 
         :                                                    
 2eau(A) : NAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDI 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : VEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAV 
         :                                                    
 2eau(A) : VEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAV 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : NQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQ 
         :                                                    
 2eau(A) : NQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQ 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : QKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAV 
         :                                                    
 2eau(A) : QKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAV 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS 
         :                                                    
 2eau(A) : ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS 
           __________________________________________________ 

           ________361_______________________________________ 
 1wpg(C) : DKTGTLTTNQMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDK 
         :                                                    
 2eau(A) : DKTGTLTTNQMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDK 
           ________361_______________________________________ 

           __________________________________________________ 
 1wpg(C) : PIRSGQFDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVE 
         :                                                    
 2eau(A) : PIRSGQFDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVE 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : KMNVFNTEVRNLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSP 
         :                                                    
 2eau(A) : KMNVFNTEVRNLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSP 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : AKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIK 
         :                                                    
 2eau(A) : AKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIK 
           __________________________________________________ 

           ______________________________________________599_ 
 1wpg(C) : EWGTGRDTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGML 
         :                                                    
 2eau(A) : EWGTGRDTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGML 
           ______________________________________________599_ 

           __________________________________________________ 
 1wpg(C) : DPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVAD 
         :                                                    
 2eau(A) : DPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVAD 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : RAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAM 
         :                                                    
 2eau(A) : RAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAM 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : TGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEG 
         :                                                    
 2eau(A) : TGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEG 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : RAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTD 
         :                                                    
 2eau(A) : RAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTD 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : GLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVG 
         :                                                    
 2eau(A) : GLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVG 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : AAAWWFMYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMA 
         :                                                    
 2eau(A) : AAAWWFMYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMA 
           __________________________________________________ 

           __________________________________________________ 
 1wpg(C) : LSVLVTIEMCNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYV 
         :                                                    
 2eau(A) : LSVLVTIEMCNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYV 
           __________________________________________________ 

           ____________________________________________       
 1wpg(C) : DPLPMIFKLKALDLTQWLMVLKISLPVIGLDEILKFIARNYLEG       
         :                                                    
 2eau(A) : DPLPMIFKLKALDLTQWLMVLKISLPVIGLDEILKFIARNYLEG       
           ____________________________________________       

Details

  Property   Value
 Conformer 1 1wpg(C)
 Conformer 2 2eau(A)
 Radius gyration for conformer 1 39.1 A
 Radius gyration for conformer 2 38.86 A
 EC Number 3.6.3.8  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP1202
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA517  GLY516  ILE188  LEU562  LYS205  LYS515  MET494  PHE487 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT