TRYPTOPHAN SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2tys(B) : *TLLNPYFGEFGGMYVPQILMPALNQLEEAFVRAQKDPEFQAQFADLLKN 
         :                                                    
 1qoq(B) : TTLLNPYFGEFGGMYVPQILMPALNQLEEAFVSAQKDPEFQAQFADLLKN 
           __________________________________________________ 

           _________________________________________94_______ 
 2tys(B) : YAGRPTALTKCQNITAGTRTTLYLKREDLLHGGAHTTNQVLGQALLAKRM 
         :                                                    
 1qoq(B) : YAGRPTALTKCQNITAGTRTTLYLKREDLLHGGAHKTNQVLGQALLAKRM 
           _________________________________________94_______ 

           __________________________________________________ 
 2tys(B) : GKSEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRL 
         :                                                    
 1qoq(B) : GKSEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRL 
           __________________________________________________ 

           ________________________________186_______________ 
 2tys(B) : MGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIV 
         :                                                    
 1qoq(B) : MGAEVIPVHSGSATLKDACNEALADWSGSYETAHYMLGTAAGPHPYPTIV 
           ________________________________186_______________ 

           __________________________________________________ 
 2tys(B) : REFQRMIGEETKAQILDKEGRLPDAVIACVGGGSNAIGMFADFINDTSVG 
         :                                                    
 1qoq(B) : REFQRMIGEETKAQILDKEGRLPDAVIACVGGGSNAIGMFADFINDTSVG 
           __________________________________________________ 

           __________________________________________________ 
 2tys(B) : LIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTADGQIEESYSIS 
         :                                                    
 1qoq(B) : LIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTADGQIEESYSIS 
           __________________________________________________ 

           __________________________________________________ 
 2tys(B) : AGLDFPSVGPQHAYLNSIGRADYVSITDDEALEAFKTLCRHEGIIPALES 
         :                                                    
 1qoq(B) : AGLDFPSVGPQHAYLNSIGRADYVSITDDEALEAFKTLCRHEGIIPALES 
           __________________________________________________ 

           ______________________________________________     
 2tys(B) : SHALAHALKMMREQPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI     
         :                                                    
 1qoq(B) : SHALAHALKMMREQPEKEQLLVVNLSGRGDKDIFTVHDILKARG**     
           ______________________________________________     

Details

  Property   Value
 Conformer 1 2tys(B)
 Conformer 2 1qoq(B)
 Radius gyration for conformer 1 19.78 A
 Radius gyration for conformer 2 20.09 A
 EC Number 4.2.1.20  
Click here to see the DynDom results or the famliy
 Trigger ligands PLP500
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA348  ALA85  ASN236  CYS230  GLN114  GLU350  GLY232  GLY233  GLY234  GLY303  GLY378  HIS86  LYS87  SER235  SER351  SER377  THR190  VAL231 
 Residues in extended bending regions contacting ligands THR190 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands THR190 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT