UDP-N-ACETYLMURAMOYL-L-ALANINE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1e0d(A) : ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAV 
         :                                                    
 4uag(A) : ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAV 
           __________________________________________________ 

           __________________________________________________ 
 1e0d(A) : ERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCR 
         :                                                    
 4uag(A) : ERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCR 
           __________________________________________________ 

           __________________________________________________ 
 1e0d(A) : EAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE 
         :                                                    
 4uag(A) : EAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE 
           __________________________________________________ 

           __________________________________________________ 
 1e0d(A) : CELYVLELSSFQLETTSSLQAVAATILNVTED------fGLQQYRAAKLR 
         :                                                    
 4uag(A) : CELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAA-lR 
           __________________________________________________ 

           __________________________________________________ 
 1e0d(A) : IYENAKVCVVNADDALTMPIaDERCVSFGVNMGDYHLNHQQGETWLRVKG 
         :                                                    
 4uag(A) : IYENAKVCVVNADDALTMPI---rCVSFGVNMGDYHLNH---eTWLRVKG 
           __________________________________________________ 

           ____________________________________________299___ 
 1e0d(A) : EKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHR 
         :                                                    
 4uag(A) : EKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHR 
           ____________________________________________299___ 

           __________________________________________________ 
 1e0d(A) : FEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADF 
         :                                                    
 4uag(A) : FEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADF 
           __________________________________________________ 

           __________________________________________________ 
 1e0d(A) : SPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQ 
         :                                                    
 4uag(A) : SPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQ 
           __________________________________________________ 

           ___________________________________                
 1e0d(A) : PGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG                
         :                                                    
 4uag(A) : PGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG                
           ___________________________________                

Details

  Property   Value
 Conformer 1 1e0d(A)
 Conformer 2 4uag(A)
 Radius gyration for conformer 1 23.97 A
 Radius gyration for conformer 2 22.64 A
 EC Number 6.3.2.9  
Click here to see the DynDom results or the famliy
 Trigger ligands UAG460
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA414  ARG37  ASN138  ASN421  ASP35  GLN162  GLY137  GLY14  GLY140  GLY73  HIS183  ILE11  LEU15  LEU416  LYS348  PHE161  PHE422  PRO72  SER159  SER415  SER71  THR16  THR321  THR36 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT