DNA Mismatch Repair Protein Muts

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name DNA Mismatch Repair Protein Muts
  Conformer 1
(PDB)
1ewq (B)
  Conformer 2
(PDB)
1ewq (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 567 0.99   1118 - 1421   1484 - 1759
2 104 0.73   1005 - 1117
3 61 0.55   1422 - 1483

Sequence


           _____________________________________________________________________________________________________________1117_______ 
 1ewq(B) : EGlKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPaGIPLRAFEAYAERLLKgFRLAVADQVEP-------vRREVTQLLTPGTLLQE 
         :                                                                                                                          
 1ewq(A) : EGlKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPaGIPLRAFEAYAERLLKgFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQE 
           ______________________________________________________________________________________________________________117_______ 

           ________________________________________________________________________________________________________________________ 
 1ewq(B) : SLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVlSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYD 
         :                                                                                                                          
 1ewq(A) : SLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVlSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYD 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1ewq(B) : PGAFrLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALL 
         :                                                                                                                          
 1ewq(A) : PGAFrLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALL 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________1421_________________________________________________________1483____ 
 1ewq(B) : GEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEkEKERE 
         :                                                                                                                          
 1ewq(A) : GEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEkEKERE 
           ____________________________________________________421__________________________________________________________483____ 

           ________________________________________________________________________________________________________________________ 
 1ewq(B) : VYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEaHELVLITGPNaGKSTFLRQTALIALLAQVGSFV 
         :                                                                                                                          
 1ewq(A) : VYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEaHELVLITGPNaGKSTFLRQTALIALLAQVGSFV 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1ewq(B) : PAEEAHLPLFDGIYTRIGAgKSTFvEeEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSY 
         :                                                                                                                          
 1ewq(A) : PAEEAHLPLFDGIYTRIGAgKSTFvEeEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSY 
           ________________________________________________________________________________________________________________________ 

           __________________________                                                                                               
 1ewq(B) : GVEVAAaGLPKEVVARARALLQA***                                                                                               
         :                                                                                                                          
 1ewq(A) : GVEVAAaGLPKEVVARARALLQAaAR                                                                                               
           __________________________                                                                                               

Morph

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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
13.8
Translation
(A)
0.6
Closure
(%)
8.0
Bending Residues
( green )
  1117 - 1118
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
13.2
Translation
(A)
-1.3
Closure
(%)
83.7
Bending Residues
( green )
  1421 - 1423
  1483 - 1484
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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