Interferon-Induced, Double-Stranded Rna- Activated Protein Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Interferon-Induced, Double-Stranded Rna- Activated Protein Kinase
  Conformer 1
(PDB)
2a1a (B)
  Conformer 2
(PDB)
2a19 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 177 0.52   313 - 319   369 - 539
2 81 0.68   259 - 312   320 - 368

Sequence


           _______________________________________________________312____319_____________________________368_______________________ 
 2a1a(B) : GAHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSsRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 
         :                                                                                                                          
 2a19(B) : *AHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYD-----rSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 
           _______________________________________________________312____319_____________________________368_______________________ 

           ________________________________________________________________________________________________________________________ 
 2a1a(B) : LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRrSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEK 
         :                                                                                                                          
 2a19(B) : LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRrSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEK 
           ________________________________________________________________________________________________________________________ 

           _____________________________                                                                                            
 2a1a(B) : TLLQKLLSKKPEDRPNTSEILRTLTVWKK                                                                                            
         :                                                                                                                          
 2a19(B) : TLLQKLLSKKPEDRPNTSEILRTLTVWKK                                                                                            
           _____________________________                                                                                            

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
10.9
Translation
(A)
0.0
Closure
(%)
100.0
Bending Residues
( green )
  312 - 313
  319 - 320
  368 - 369
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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