DynDom - Protein Domain Motions

Aldo-Keto Reductase Family 1 Member C2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Aldo-Keto Reductase Family 1 Member C2
Conformer 1 (PDB)	1xjb (A)
Conformer 2 (PDB)	1j96 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	292	0.31	6 - 120 128 - 128 139 - 310 318 - 321
2	24	0.3	121 - 127 129 - 138 311 - 317

Sequence

`_______________________________________________________________________________________________________________________1` `1xjb(A) : SVDDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHF` `:` `1j96(A) : **DDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHF` `_______________________________________________________________________________________________________________________1` `20____127________138____________________________________________________________________________________________________` `1xjb(A) : PVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLED` `:` `1j96(A) : PVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLED` `20____127________138____________________________________________________________________________________________________` `_____________________________________________________________________310____317______` `1xjb(A) : PVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY` `:` `1j96(A) : PVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY` `_____________________________________________________________________310____317______`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	4.2
Translation (A)	-0.1
Closure (%)	87.6
Bending Residues ( green )	120 - 121 127 - 129 138 - 139 310 - 311 317 - 318
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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