DynDom - Protein Domain Motions

Bifunctional Purine Biosynthesis Protein Purh

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Bifunctional Purine Biosynthesis Protein Purh
Conformer 1 (PDB)	2b1i (B)
Conformer 2 (PDB)	2b1g (D)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	411	0.91	6 - 254 260 - 285 287 - 289 293 - 394 428 - 433 437 - 448 450 - 453 533 - 538 555 - 555 590 - 591
2	175	0.76	255 - 259 286 - 286 290 - 292 395 - 427 434 - 436 449 - 449 454 - 532 539 - 554 556 - 589

Sequence

`________________________________________________________________________________________________________________________` `2b1i(B) : RQQLALLSVSEKAGLVEFARSLNALGLGLIASGGTATALRDAGLPVRDVSDLTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMNKQDFSLVRVVVCNLYPFVKTVSSPGVTVPEAVE` `:` `2b1g(D) : RQQLALLSVSEKAGLVEFARSLNALGLGLIASGGTATALRDAGLPVRDVSDLTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMNKQDFSLVRVVVCNLYPFVKTVSSPGVTVPEAVE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2b1i(B) : KIDIGGVALLRAAAKNHARVTVVCDPADYSSVAKEMAASKDKDTSVETRRHLALKAFTHTAQYDAAISDYFRKEYSKGVSQLPLRYGMNPHQSPAQLYTTRPKLPLTVVNGSPGFINLCD` `:` `2b1g(D) : KIDIGGVALLRAAAKNHARVTVVCDPADYSSVAKEMAASKDKDTSVETRRHLALKAFTHTAQYDAAISDYFRKEYSKGVSQLPLRYGMNPHQSPAQLYTTRPKLPLTVVNGSPGFINLCD` `________________________________________________________________________________________________________________________` `________254__259_______________________285_289__________________________________________________________________________` `2b1i(B) : ALNAWQLVKELKQALGIPAAASFKHVSPAGAAVGIPLSEEEAQVCMVHDLHKTLTPLASAYARSRGADRMSSFGDFIALSDICDVPTAKIISREVSDGVVAPGYEEEALKILSKKKNGGY` `:` `2b1g(D) : ALNAWQLVKELKQALGIPAAASFKHVSPAGAAVGIPLSEEEAQVCMVHDLHKTLTPLASAYARSRGADRMSSFGDFIALSDICDVPTAKIISREVSDGVVAPGYEEEALKILSKKKNGGY` `________254__259_______________________285_289__________________________________________________________________________` `____________________________394______________________________427___433____________448__453______________________________` `2b1i(B) : CVLQMDPNYEPDDNEIRTLYGLQLMQKRNNAVIDRSLFKNIVTKNKTLPESAVRDLIVASIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGV` `:` `2b1g(D) : CVLQMDPNYEPDDNEIRTLYGLQLMQKRNNAVIDRSLFKNIVTKNKTLPESAVRDLIVASIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGV` `____________________________394______________________________427___433____________448__453______________________________` `______________________________________________532___538_____________554________________________________589____` `2b1i(B) : KRAEVSNAIDQYVTGTIGEDEDLVKWQAMFEEVPAQLTEAEKKQWIAKLTAVSLSSDAFFPFRDNVDRAKRIGVQFIVAPSGSAADEVVIEACNELGITLIHTNLRLFHH` `:` `2b1g(D) : KRAEVSNAIDQYVTGTIGEDEDLVKWQAMFEEVPAQLTEAEKKQWIAKLTAVSLSSDAFFPFRDNVDRAKRIGVQFIVAPSGSAADEVVIEACNELGITLIHTNLRLFHH` `______________________________________________532___538_____________554________________________________589____`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	3.8
Translation (A)	1.6
Closure (%)	9.3
Bending Residues ( green )	254 - 255 259 - 260 285 - 287 289 - 290 292 - 293 394 - 395 427 - 428 433 - 434 436 - 437 448 - 450 453 - 454 532 - 533 538 - 539 554 - 556 589 - 590
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

Download and extract PyMOL PML script file

Download