Calmodulin-Sensitive Adenylate Cyclase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Calmodulin-Sensitive Adenylate Cyclase
  Conformer 1
(PDB)
1k90 (B)
  Conformer 2
(PDB)
1k90 (A)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 431 1.41   298 - 657   704 - 728   738 - 766   776 - 794
2 26 4.15   658 - 703   729 - 737   767 - 775

Sequence


           ________________________________________________________________________________________________________________________ 
 1k90(B) : **DVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIE 
         :                                                                                                                          
 1k90(A) : RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIE 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1k90(B) : ELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPN--eKQKGVTN 
         :                                                                                                                          
 1k90(A) : ELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTN 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________________________________________________________________651 
 1k90(B) : LLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITK 
         :                                                                                                                          
 1k90(A) : LLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITK 
           _____________________________________________________________________________________________________________________651 

           _______________________________703______________________728______737_________________________765___775__________________ 
 1k90(B) : AKINTIP----------------sVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKfKLLYKQLNFTENETDNFEVF 
         :                                                                                                                          
 1k90(A) : AKINTIPTSAEFIKNLSSIRRSSsVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKfKLLYKQLNFTENETDNFEVF 
           _______________________________703______________________728______737_________________________765___775__________________ 

           _____                                                                                                                    
 1k90(B) : QKIID                                                                                                                    
         :                                                                                                                          
 1k90(A) : QKIID                                                                                                                    
           _____                                                                                                                    

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
22.5
Translation
(A)
-0.2
Closure
(%)
98.8
Bending Residues
( green )
  651 - 658
  703 - 707
  728 - 729
  737 - 746
  765 - 767
  775 - 781
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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