Camp And Camp-Inhibited Cgmp 3',5'-Cyclic Phosphodiesterase 10A

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Camp And Camp-Inhibited Cgmp 3',5'-Cyclic Phosphodiesterase 10A
  Conformer 1
(PDB)
2our (B)
  Conformer 2
(PDB)
2ous (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 280 1.19   448 - 692   719 - 769
2 26 0.56   693 - 718

Sequence


           ________________________________________________________________________________________________________________________ 
 2our(B) : SHMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDL 
         :                                                                                                                          
 2ous(A) : SHMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDL 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________________________________________________________________681____ 
 2our(B) : DHRGFs----------------TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACALCSVTKLWPVT 
         :                                                                                                                          
 2ous(A) : DHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACALCSVTKLWPVT 
           _________________________________________________________________________________________________________________681____ 

           ______________________________718__________________________________________________________                              
 2our(B) : KLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWIS                              
         :                                                                                                                          
 2ous(A) : KLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEET*****                              
           ______________________________718__________________________________________________________                              

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
49.0
Translation
(A)
-0.3
Closure
(%)
96.9
Bending Residues
( green )
  681 - 694
  718 - 723
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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