DynDom - Protein Domain Motions

Carboxyl-Terminal Src Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Carboxyl-Terminal Src Kinase
Conformer 1 (PDB)	1k9a (B)
Conformer 2 (PDB)	1k9a (F)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	134	0.86	8 - 71 180 - 229 232 - 236 239 - 241 249 - 255 262 - 266
2	111	0.96	74 - 179 230 - 231 256 - 258
3	182	0.67	237 - 238 242 - 248 267 - 448

Sequence

`__________________________________________________________________71____________________________________________________` `1k9a(B) : IQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCE` `:` `1k9a(F) : **ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCE` `__________________________________________________________________71____________________________________________________` `_____________________________________________________179_______________________________________________229____236__241__` `1k9a(B) : GKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL` `:` `1k9a(F) : GKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL` `_____________________________________________________179_______________________________________________229____236__241__` `__248____255________266_________________________________________________________________________________________________` `1k9a(B) : RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAgKLPVKWTAPEALREKKFSTKSDV` `:` `1k9a(F) : RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---pVKWTAPEALREKKFSTKSDV` `__248____255________266_________________________________________________________________________________________________` `_________________________________________________________________________________` `1k9a(B) : WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL` `:` `1k9a(F) : WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL` `_________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	13.4
Translation (A)	0.0
Closure (%)	21.3
Bending Residues ( green )	71 - 76 179 - 180 229 - 232 255 - 263
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	15.1
Translation (A)	0.1
Closure (%)	19.0
Bending Residues ( green )	236 - 239 241 - 242 248 - 249 266 - 267
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Shear

PyMOL Script

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