DynDom - Protein Domain Motions

Complement C3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Complement C3
Conformer 1 (PDB)	2a73 (B)
Conformer 2 (PDB)	2hr0 (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	567	19.64	729 - 961 1265 - 1272 1306 - 1639
2	297	0.23	962 - 1264
3	23	1.55	1281 - 1303

Sequence

`________________________________________________________________________________________________________________________` `2a73(B) : VQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARAlDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITT` `:` `2hr0(B) : *******************************************************************SNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITT` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2a73(B) : WEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFI` `:` `2hr0(B) : WEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFI` `________________________________________________________________________________________________________________________` `___________________________________________________________961__________________________________________________________` `2a73(B) : SDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEK` `:` `2hr0(B) : SDGVRKSLKVVPEGIR---tVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETR-lLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEK` `___________________________________________________________961__________________________________________________________` `________________________________________________________________________________________________________________________` `2a73(B) : RQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQE------nNNEKDMALTAFVLISLQEAKDICEEQ` `:` `2hr0(B) : RQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQ` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________________________________________1` `2a73(B) : VNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQ` `:` `2hr0(B) : VNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQ` `_______________________________________________________________________________________________________________________1` `262_____________________________________1303____________________________________________________________________________` `2a73(B) : YQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMS` `:` `2hr0(B) : YQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMS` `262_____________________________________1303____________________________________________________________________________` `________________________________________________________________________________________________________________________` `2a73(B) : ILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQ` `:` `2hr0(B) : ILDISMMTGFAPDTDDLKQLANGVDRYISKYELDK----rNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2a73(B) : KSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEE` `:` `2hr0(B) : KSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEE` `________________________________________________________________________________________________________________________` `______________________` `2a73(B) : NQKQCQDLGAFTESMVVFGCPN` `:` `2hr0(B) : NQKQCQDLGAFTESMVVFGCPN` `______________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	151.4
Translation (A)	-27.4
Closure (%)	44.4
Bending Residues ( green )	961 - 964 1262 - 1272
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	178.1
Translation (A)	-19.0
Closure (%)	17.7
Bending Residues ( green )	1265 - 1281 1303 - 1335
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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