Dicer

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Dicer
  Conformer 1
(PDB)
2ffl (A)
  Conformer 2
(PDB)
2ffl (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 411 1.09   278 - 291   297 - 301   334 - 386   388 - 750
2 307 0.37   2 - 277   292 - 296   302 - 333   387 - 387

Sequence


           ________________________________________________________________________________________________________________________ 
 2ffl(A) : GAMHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYFEAGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFPRFISNPPQFATLAFLPLLSP 
         :                                                                                                                          
 2ffl(B) : *AMHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYFEAGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFPRFISNPPQFATLAFLPLLSP 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2ffl(A) : TSPLDLRALMVTAQLMCDAKRLSDElSASLHGRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAHNIHLRAADLPLVAAVRLDDLKDHQIPAPGSdDLAPKLRFLPPE 
         :                                                                                                                          
 2ffl(B) : TSPLDLRALMVTAQLMCDAKRLSDElSASLHGRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAHNIHLRAADLPLVAAVRLDDLKDHQIPAPGSdDLAPKLRFLPPE 
           ________________________________________________________________________________________________________________________ 

           _____________________________277___________291__296__301_____________________________333________________________________ 
 2ffl(A) : LCLLLPDEFDLIRVQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGLRLDQGRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCLFPDASVGTLVE 
         :                                                                                                                          
 2ffl(B) : LCLLLPDEFDLIRVQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGLRLDQGRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCLFPDASVGTLVE 
           _____________________________277___________291__296__301_____________________________333________________________________ 

           __________________386___________________________________________________________________________________________________ 
 2ffl(A) : LKMELVRNEALNYLVQTLGLPQLAEFSNNL--kSKTWADMYEEIVGSIFTGPNGIYGCEEFLAKTLMSPEHSKTaCPDAVTKASKRVCMGEAGAHEFRSLVDYACEQGISVFCSSRVSTM 
         :                                                                                                                          
 2ffl(B) : LKMELVRNEALNYLVQTLGLPQLAE--nNLVAKSKTWADMYEEIVGSIFTGPNGIYGCEEFLAKTLMSPEHSKTaCPDAVTKASKRVCMGEAGAHEFRSLVDYACEQGISVFCSSRVSTM 
           __________________386___________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2ffl(A) : FLERLRDIPAEDMLDWYRLGIQFSHRSGLSGPGGVVSVIDIMTHLARGLWLGSPGFYVEQpPTIPVLYIYHRSVQCPVLYGSLTtGPVASKVLALYEKILAYESSGGSKHIAAQTVSRSL 
         :                                                                                                                          
 2ffl(B) : FLERLRDIPAEDMLDWYRLGIQFSHRSGLSG----vSVIDIMTHLARGLWLGSPGFYVE-pPTIPVLYIYHRSVQCPVLYGSLTtGPVASKVLALYEKILAYESSGGSKHIAAQTVSRSL 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2ffl(A) : AVPIPSGTIPFLIRLLQIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLTEGALTRMRQSAETNSVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTFEAILAAILLACGEEAAGA 
         :                                                                                                                          
 2ffl(B) : AVPIPSGTIPFLIRLLQIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLTEGALTRMRQSAETNSVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTFEAILAAILLACGEEAAGA 
           ________________________________________________________________________________________________________________________ 

           ______________                                                                                                           
 2ffl(A) : FVREHVLPQVVADA                                                                                                           
         :                                                                                                                          
 2ffl(B) : FVREHVLPQVVADA                                                                                                           
           ______________                                                                                                           

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
5.3
Translation
(A)
-0.2
Closure
(%)
51.2
Bending Residues
( green )
  277 - 278
  291 - 292
  296 - 297
  301 - 302
  333 - 334
  386 - 388
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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