DNA Topoisomerase II, Alpha Isozyme

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name DNA Topoisomerase II, Alpha Isozyme
  Conformer 1
(PDB)
1zxm (B)
  Conformer 2
(PDB)
1zxn (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 234 0.72   31 - 264
2 128 0.73   265 - 409

Sequence


           ________________________________________________________________________________________________________________________ 
 1zxm(B) : SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTS 
         :                                                                                                                          
 1zxn(B) : SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTS 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________________________________________________________________264____ 
 1zxm(B) : SNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFR 
         :                                                                                                                          
 1zxn(B) : SNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFR 
           _________________________________________________________________________________________________________________264____ 

           ________________________________________________________________________________________________________________________ 
 1zxm(B) : SYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNvKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQ 
         :                                                                                                                          
 1zxn(B) : SYVDMYLK----------kVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKK--kAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQ 
           ________________________________________________________________________________________________________________________ 

           _______________________________                                                                                          
 1zxm(B) : LSEKFIKAAIGCGIVESI*************                                                                                          
         :                                                                                                                          
 1zxn(B) : LSEKFIKAAIGCGIVESILNWVKFKAQVQLN                                                                                          
           _______________________________                                                                                          

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
9.5
Translation
(A)
0.6
Closure
(%)
60.2
Bending Residues
( green )
  264 - 265
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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