Farnesyl-Diphosphate Farnesyltransferase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Farnesyl-Diphosphate Farnesyltransferase
  Conformer 1
(PDB)
1ezf (B)
  Conformer 2
(PDB)
1ezf (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 205 0.53   65 - 66   141 - 143   145 - 147   157 - 280   283 - 368
2 111 0.42   40 - 64   67 - 140   144 - 144   148 - 156   281 - 282

Sequence


           _____________________________64_________________________________________________________________________140____147______ 
 1ezf(B) : NSLSNSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIG 
         :                                                                                                                          
 1ezf(A) : ****NSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIG 
           _____________________________64_________________________________________________________________________140____147______ 

           156_____________________________________________________________________________________________________________________ 
 1ezf(B) : MAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDV 
         :                                                                                                                          
 1ezf(A) : MAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDV 
           156_____________________________________________________________________________________________________________________ 

           ____280________________________________________________________________________________                                  
 1ezf(B) : ITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAV---aTNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQN                                  
         :                                                                                                                          
 1ezf(A) : ITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIdATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQN                                  
           ____280________________________________________________________________________________                                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
5.6
Translation
(A)
0.2
Closure
(%)
45.4
Bending Residues
( green )
  64 - 67
  140 - 141
  143 - 145
  147 - 148
  156 - 157
  280 - 283
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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