Glutathione-Requiring Prostaglandin D Synthase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Glutathione-Requiring Prostaglandin D Synthase
  Conformer 1
(PDB)
2cvd (B)
  Conformer 2
(PDB)
1v40 (D)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 171 0.32   4 - 100   124 - 197
2 23 0.46   101 - 123

Sequence


           ________________________________________________________________________________________________99_____________________1 
 2cvd(B) : PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLT 
         :                                                                                                                          
 1v40(D) : PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLT 
           _______________________________________________________________________________________________699_____________________7 

           23____________________________________________________________________________                                           
 2cvd(B) : YNAPHLMQDLDTYLGGREWLIGMSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL                                           
         :                                                                                                                          
 1v40(D) : YNAPHLMQDLDTYLGGREWLIGMSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL                                           
           23____________________________________________________________________________                                           

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
17.9
Translation
(A)
-0.6
Closure
(%)
71.2
Bending Residues
( green )
  99 - 101
  123 - 128
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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