Haematopoetic Cell Kinase (Hck)

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Haematopoetic Cell Kinase (Hck)
  Conformer 1
(PDB)
1qcf (A)
  Conformer 2
(PDB)
2c0t (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 246 1.46   85 - 151   153 - 153   157 - 317   323 - 337   403 - 410
2 170 0.59   152 - 152   154 - 156   318 - 322   338 - 402   411 - 519

Sequence


           ____________________________________________________________________151_________________________________________________ 
 1qcf(A) : SGIRIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVK 
         :                                                                                                                          
 2c0t(B) : ***RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVK 
           ____________________________________________________________________126_________________________________________________ 

           _________________________________________________________________________________________________________________317____ 
 1qcf(A) : HYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDK 
         :                                                                                                                          
 2c0t(B) : HYKIRT----gFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDK 
           _________________________________________________________________________________________________________________291____ 

           _____________337______________________________________________________________402_____410_______________________________ 
 1qcf(A) : LVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTI 
         :                                                                                                                          
 2c0t(B) : LVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGlARVI-------------pIKWTAPEAINFGSFTI 
           _____________311______________________________________________________________376_____384_______________________________ 

           _________________________________________________________________________________________                                
 1qcf(A) : KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQeEIP                                
         :                                                                                                                          
 2c0t(B) : KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQeEIP                                
           _________________________________________________________________________________________                                

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
12.3
Translation
(A)
-0.9
Closure
(%)
93.4
Bending Residues
( green )
  151 - 157
  317 - 323
  337 - 339
  402 - 403
  410 - 426
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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