Heavy Chain Of A Vegf Binding Antibody

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Heavy Chain Of A Vegf Binding Antibody
  Conformer 1
(PDB) 		1n8z (B)
  Conformer 2
(PDB) 		2fjg (B)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 119 2.59   4 - 122
2 90 0.56   123 - 217

Sequence


           _______________________________________________________________________________________________________________________1 
 1n8z(B) : EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS 
         :                                                                                                                          
 2fjg(B) : EVQLVESGGGLVQPGGSLRLSCAASGFTISDYWIHWVRQAPGKGLEWVAGITPAGGYTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARFVFFLPYAMDYWGQGTLVTVSS 
           _______________________________________________________________________________________________________________________1 

           22_____________________________________________________________________________________________________                  
 1n8z(B) : ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP***                  
         :                                                                                                                          
 2fjg(B) : ASTKGPSVFPLAPSS-----gTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC                  
           22_____________________________________________________________________________________________________                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		20.3
Translation
(A) 		1.4
Closure
(%) 		96.7
Bending Residues
( green ) 		  122 - 125
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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