Importin Alpha Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Importin Alpha Subunit
  Conformer 1
(PDB)
1wa5 (B)
  Conformer 2
(PDB)
1ee4 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 231 0.85   261 - 267   284 - 507
2 188 0.56   89 - 260   268 - 283

Sequence


           ________________________________________________________________________________________________________________________ 
 1wa5(B) : fVPEYRRTeLRRRRDTQQVELRKAKRDEALAKRRNFqELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVV 
         :                                                                                                                          
 1ee4(B) : ************************************QELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVV 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________________________________260___266______________283_______ 
 1wa5(B) : DADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQE 
         :                                                                                                                          
 1ee4(B) : DADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQE 
           _______________________________________________________________________________________260___266______________283_______ 

           ________________________________________________________________________________________________________________________ 
 1wa5(B) : AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNA 
         :                                                                                                                          
 1ee4(B) : AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEDKTKKEACWAISNA 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________________________________________________                  
 1wa5(B) : SSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEE                  
         :                                                                                                                          
 1ee4(B) : SSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYF****                  
           _______________________________________________________________________________________________________                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
13.6
Translation
(A)
-0.9
Closure
(%)
78.7
Bending Residues
( green )
  260 - 261
  266 - 270
  283 - 284
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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