Inositol-Trisphosphate 3-Kinase A

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Inositol-Trisphosphate 3-Kinase A
  Conformer 1
(PDB)
1w2d (B)
  Conformer 2
(PDB)
1w2f (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 221 0.83   199 - 278   317 - 459
2 20 0.67   283 - 315

Sequence


           _________________________________________________________________________________________278____________________________ 
 1w2d(B) : **********SFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKA----kLRKDMYKKMLAVDP--------- 
         :                                                                                                                          
 1w2f(A) : SWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARL-aDALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCK-gVRTYLEEELTKARERPKLRKD-yKK-lAVDPEAPTEEEHA 
           _________________________________________________________________________________________278____________________________ 

           ______315_______________________________________________________________________________________________________________ 
 1w2d(B) : --aVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDG 
         :                                                                                                                          
 1w2f(A) : QRAVTKPRY-qWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDG 
           ______315_______________________________________________________________________________________________________________ 

           ___________________________________                                                                                      
 1w2d(B) : QILDHRRPWEEGNREDGYLLGLDNLIGILASLAER                                                                                      
         :                                                                                                                          
 1w2f(A) : QILDHRRPWEEGNREDGYLLGLDNLIGILASLAER                                                                                      
           ___________________________________                                                                                      

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
16.6
Translation
(A)
-0.9
Closure
(%)
46.7
Bending Residues
( green )
  278 - 283
  315 - 318
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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