Isocitrate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Isocitrate Dehydrogenase
  Conformer 1
(PDB)
1xkd (B)
  Conformer 2
(PDB)
1xkd (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 212 0.86   8 - 133   332 - 401   403 - 424
2 199 0.8   134 - 331   402 - 402

Sequence


           ________________________________________________________________________________________________________________________ 
 1xkd(B) : *SPPCTTEELSPPPGGSLVEYSGGSLRVPDNPVVAFIRGDGVGPEVVESALKVVDAAVKKV--gSRRIVWWELLAGHLAREKCGELLPKATLEGIRLARVALKGPLETPVGTGYRSLNVA 
         :                                                                                                                          
 1xkd(A) : ASPPCTTEELSPPPGGSLVEYSGGSLRVPDNPVVAFIRGDGVGPEVVESALKVVDAAVKKVYGGSRRIVWWELLAGHLAREKCGELLPKATLEGIRLARVALKGPLETPV----rSLNVA 
           ________________________________________________________________________________________________________________________ 

           ______133_______________________________________________________________________________________________________________ 
 1xkd(B) : IRQALDLYANIRPVRYYGQPAPHKYADRVDMVIFRENTEDVYAGIEWPHDSPEAARIRRFLAEEFGISIREDAGIGVKPISRFATRRLMERALEWALRNGNTVVTIMHKGNIMKYTEGAF 
         :                                                                                                                          
 1xkd(A) : IRQALDLYANIRPVRYYGQPAPHKYADRVDMVIFRENTEDVYAGIEWPHDSPEAARIRRFLAEEFGISIREDAGIGVKPISRFATRRLMERALEWALRNGNTVVTIMHKGNIMKYTEGAF 
           ______133_______________________________________________________________________________________________________________ 

           ____________________________________________________________________________________331_________________________________ 
 1xkd(B) : MRWAYEVALEKFREHVVTEQEVQEKYGGVRPEGKILVNDRIADNMLQQIITRPWDYQVIVAPNLNGDYISDAASALVGGIGMAAGMNMGDGIAVAEPVHGTAPKYAGKDLINPSAEILSA 
         :                                                                                                                          
 1xkd(A) : MRWAYEVALEKFREHVVTEQEVQEKYGGVRPEGKILVNDRIADNMLQQIITRPWDYQVIVAPNLNGDYISDAASALVGGIGMAAGMNMGDGIAVAEPVHGTAPKYAGKDLINPSAEILSA 
           ____________________________________________________________________________________331_________________________________ 

           __________________________________401__________________________________                                                  
 1xkd(B) : SLLIGEFMGWREVKSIVEYAIRKAVQSKKVTQDLARHMPGVQPLRTSEYTETLIAYIDEADL*********                                                  
         :                                                                                                                          
 1xkd(A) : SLLIGEFMGWREVKSIVEYAIRKAVQSKKVTQDLARHMPGVQPLRTSEYTETLIAYIDEADLNEVLAGKRG                                                  
           __________________________________401__________________________________                                                  

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
19.8
Translation
(A)
-0.5
Closure
(%)
93.0
Bending Residues
( green )
  133 - 134
  331 - 332
  401 - 405
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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