DynDom - Protein Domain Motions

Ketol-Acid Reductoisomerase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Ketol-Acid Reductoisomerase
Conformer 1 (PDB)	1yrl (D)
Conformer 2 (PDB)	1yrl (A)
Window Length	9
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	328	0.4	7 - 18 97 - 98 102 - 143 153 - 155 174 - 176 210 - 474 476 - 476
2	134	0.54	19 - 96 99 - 101 144 - 152 156 - 173 177 - 209 475 - 475 477 - 485

Sequence

`______________18____________________________________________________________________________96__101_____________________` `1yrl(D) : NYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIV------lNQGLNMRDSGLDISYALRKEAIAE-----------gFKVGTYEELIPQADLVINLTPDKQHSDVVRTVQPLM` `:` `1yrl(A) : NYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVINLTPDKQHSDVVRTVQPLM` `______________18____________________________________________________________________________96__101_____________________` `__________________143______152__________________173_________________________________209_________________________________` `1yrl(D) : KDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVE` `:` `1yrl(A) : KDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVE` `__________________143______152__________________173_________________________________209_________________________________` `________________________________________________________________________________________________________________________` `1yrl(D) : EGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMI` `:` `1yrl(A) : EGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMI` `________________________________________________________________________________________________________________________` `_____________________________________________________________________________________________________________474________` `1yrl(D) : AMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNGQLRDVNEAIRSHAIEQVGKKLRGYMT` `:` `1yrl(A) : AMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNGQLRDVNEAIRSHAIEQVGKKLRGYMT` `_____________________________________________________________________________________________________________474________` `_______` `1yrl(D) : DMKRIAV` `:` `1yrl(A) : DMKRIAV` `_______`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	4.0
Translation (A)	-0.1
Closure (%)	35.7
Bending Residues ( green )	18 - 19 96 - 99 101 - 102 143 - 144 152 - 153 155 - 156 173 - 174 176 - 177 209 - 211 474 - 477
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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