ANTHRANILATE SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1i7s(C) : TKPQLTLLKVQASYRGDPTTLFHQLCGARPATLLLESAE------lQSLL           :                                                      1i7q(A) : TKPQLTLLKVQASYRGDPTTLFHQLCGARPATLLLESAEINDKQNLQSLL             __________________________________________________             __________________________________________________   1i7s(C) : VIDSALRITALGHTVSVQALTANGPALLPLLDEALPPEVRNQARPNGREL           :                                                      1i7q(A) : VIDSALRITALGHTVSVQALTANGPALLPLLDEALPPEVRNQARPNGREL             __________________________________________________             __________________________________________________   1i7s(C) : TFPAIDAVQDEDARLRSLSVFDALRTILTLVDSPADEREAVMLGGLFAYD           :                                                      1i7q(A) : TFPAIDAVQDEDARLRSLSVFDALRTILTLVDSPADEREAVMLGGLFAYD             __________________________________________________             __________________________________________________   1i7s(C) : LVAGFENLPALRQDQRCPDFCFYLAETLLVLDHQRGSARLQASVFSEQAS           :                                                      1i7q(A) : LVAGFENLPALRQDQRCPDFCFYLAETLLVLDHQRGSARLQASVFSEQAS             __________________________________________________             __________________________________________________   1i7s(C) : EAQRLQHRLEQLQAELQQPPQPIPHQKLENMQLSCNQSDEEYGAVVSELQ           :                                                      1i7q(A) : EAQRLQHRLEQLQAELQQPPQPIPHQKLENMQLSCNQSDEEYGAVVSELQ             __________________________________________________             __________________________________________________   1i7s(C) : EAIRQGEIFQVVPSRRFSLPCPAPLGPYQTLKDNNPSPYMFFMQDDDFTL           :                                                      1i7q(A) : EAIRQGEIFQVVPSRRFSLPCPAPLGPYQTLKDNNPSPYMFFMQDDDFTL             __________________________________________________             306______315__320_________________________________   1i7s(C) : FGASPESALKYDAGNRQIEIYPIAGTRPRGRRADGSLDLDLDSRIELEMR           :                                                      1i7q(A) : FGASPESALKYDAGNRQIEIYPIAGTRPRGRRADGSLDLDLDSRIELEMR             306______315__320_________________________________             ___________________375____________________________   1i7s(C) : TDHKELAEHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLVSRV           :                                                      1i7q(A) : TDHKELAEHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLVSRV             ___________________375____________________________             _407____414_______________________________________   1i7s(C) : VGTLRADLDVLHAYQACMNMGTLSGAPKVRAMQLIAALRSTRRGSYGGRV           :                                                      1i7q(A) : VGTLRADLDVLHAYQACMNMGTLSGAPKVRAMQLIAALRSTRRGSYGGRV             _407____414_______________________________________             __________________________________________________   1i7s(C) : GYFTAVRNLDTCIVIRSAYVEDGHRTVQAGAGVVQDSIPEREADETRNKA           :                                                      1i7q(A) : GYFTAVRNLDTCIVIRSAYVEDGHRTVQAGAGVVQDSIPEREADETRNKA             __________________________________________________             _________________                                    1i7s(C) : RAVLRAIATAHHAKEVF                                            :                                                      1i7q(A) : RAVLRAIATAHHAKEVF                                              _________________

Details

Property   Value  Conformer 1 1i7s(C)  Conformer 2 1i7q(A)  Radius gyration for conformer 1 22.64 A  Radius gyration for conformer 2 22.58 A  EC Number 4.1.3.27   Click here to see the DynDom results or the famliy  Trigger ligands PYR1601  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands No  Residues in enzyme contacting ligands ALA482  ARG469  GLY483  ILE468  LYS502  TYR449  VAL265   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT