PROTEIN (CATALASE HPII)
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1ggk(C) : DSLAPEDGSHRPAAEPTPPGAQPTAPGSLKAPDTRNEKLNSLEDVRKGSE           :                                                      1gg9(A) : DSLAPEDGSHRPAAEPTPPGAQPTAPGSLKAPDTRNEKLNSLEDVRKGSE             __________________________________________________             __________________________________________________   1ggk(C) : NYALTTNQGVRIADDQNSLRAGSRGPTLLEDFILREKITHFDHERIPERI           :                                                      1gg9(A) : NYALTTNQGVRIADDQNSLRAGSRGPTLLEDFILREKITHFDHERIPERI             __________________________________________________             __________________________________________________   1ggk(C) : VHARGSAAHGYFQPYKSLSDITKADFLSDPNKITPVFVRFSTVQGGAGSA           :                                                      1gg9(A) : VNARGSAAHGYFQPYKSLSDITKADFLSDPNKITPVFVRFSTVQGGAGSA             __________________________________________________             __________________________________________________   1ggk(C) : DTVRDIRGFATKFYTEEGIFDLVGHNTPIFFIQDAHKFPDFVHAVKPEPH           :                                                      1gg9(A) : DTVRDIRGFATKFYTEEGIFDLVGNNTPIFFIQDAHKFPDFVHAVKPEPH             __________________________________________________             __________________________________________________   1ggk(C) : WAIPQGQSAHDTFWDYVSLQPETLHNVMWAMSDRGIPRSYRTMEGFGIHT           :                                                      1gg9(A) : WAIPQGQSAHDTFWDYVSLQPETLHNVMWAMSDRGIPRSYRTMEGFGIHT             __________________________________________________             __________________________________________________   1ggk(C) : FRLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGRDPDFHRRELWEAI           :                                                      1gg9(A) : FRLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGRDPDFHRRELWEAI             __________________________________________________             __________________________________________________   1ggk(C) : EAGDFPEYELGFQLIPEEDEFKFDFDLLDPTKLIPEELVPVQRVGKMVLN           :                                                      1gg9(A) : EAGDFPEYELGFQLIPEEDEFKFDFDLLDPTKLIPEELVPVQRVGKMVLN             __________________________________________________             __________________________________________________   1ggk(C) : RNPDNFFAENEQAAFHPGHIVPGLDFTNDPLLQGRLFSYTDTQISRLGGP           :                                                      1gg9(A) : RNPDNFFAENEQAAFHPGHIVPGLDFTNDPLLQGRLFSYTDTQISRLGGP             __________________________________________________             __________________________________________________   1ggk(C) : NFHEIPINRPTCPYHNFQRDGMHRMGIDTNPANYEPNSINDNWPRETPPG           :                                                      1gg9(A) : NFHEIPINRPTCPYHNFQRDGMHRMGIDTNPANYEPNSINDNWPRETPPG             __________________________________________________             __________________________________________________   1ggk(C) : PKRGGFESYQERVEGNKVRERSPSFGEYYSHPRLFWLSQTPFEQRHIVDG           :                                                      1gg9(A) : PKRGGFESYQERVEGNKVRERSPSFGEYYSHPRLFWLSQTPFEQRHIVDG             __________________________________________________             __________________________________________________   1ggk(C) : FSFELSKVVRPYIRERVVDQLAHIDLTLAQAVAKNLGIELTDDQLNITPP           :                                                      1gg9(A) : FSFELSKVVRPYIRERVVDQLAHIDLTLAQAVAKNLGIELTDDQLNITPP             __________________________________________________             __________________________________________________   1ggk(C) : PDVNGLKKDPSLSLYAIPDGDVKGRVVAILLNDEVRSADLLAILKALKAK           :                                                      1gg9(A) : PDVNGLKKDPSLSLYAIPDGDVKGRVVAILLNDEVRSADLLAILKALKAK             __________________________________________________             ____633_____________________657___________________   1ggk(C) : GVHAKLLYSRMGEVTADDGTVLPIAATFAGAPSLTVDAVIVPCGNIADIA           :                                                      1gg9(A) : GVHAKLLYSRMGEVTADDGTVLPIAATFAGAPSLTVDAVIVPCGNIADIA             ____633_____________________657___________________             __________________________________________________   1ggk(C) : DNGDANYYLMEAYKHLKPIALAGDARKFKATIKIADQGEEGIVEADSADG           :                                                      1gg9(A) : DNGDANYYLMEAYKHLKPIALAGDARKFKATIKIADQGEEGIVEADSADG             __________________________________________________             ___________________________                          1ggk(C) : SFMDELLTLMAAHRVWSRIPKIDKIPA                                  :                                                      1gg9(A) : SFMDELLTLMAAHRVWSRIPKIDKIPA                                    ___________________________

Details

Property   Value  Conformer 1 1ggk(C)  Conformer 2 1gg9(A)  Radius gyration for conformer 1 28.62 A  Radius gyration for conformer 2 28.11 A  EC Number 1.11.1.6   Click here to see the DynDom results or the famliy  Trigger ligands HEM760  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands No  Residues in enzyme contacting ligands ASP118   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT