Chorismate synthase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1qxo(A) : RYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYGRGGRkIE           :                                                      1qxo(B) : RYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYGRGGRkIE             __________________________________________________             __________________________________________________   1qxo(A) : NDQVVFTSGVRHGKTTGAPITdVINKDHQKWLDIsAEDIEDRLKSKRKIT           :                                                      1qxo(B) : NDQVVFTSGVRHGKTTGAPITdVINKDHQKWLDIsAEDIEDRLKSKRKIT             __________________________________________________             __________________________________________________   1qxo(A) : HPRPGHADLVGGIKYRFDDLRNSLERSSARETTrVAVGAVAKRLLAELDe           :                                                      1qxo(B) : HPRPGHADLVGGIKYRFDDLRNSLERSSARETTrVAVGAVAKRLLAELDe             __________________________________________________             __________________________________________________   1qxo(A) : IANHVVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQ           :                                                      1qxo(B) : IANHVVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQ             __________________________________________________             __________________________________________________   1qxo(A) : IKRDGDTIGGVVETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGV           :                                                      1qxo(B) : IKRDGDTIGGVVETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGV             __________________________________________________             ________________________________________________30   1qxo(A) : EFGLGFEAGYRKGSQVdEILWSKEDGYTRRTNNLGGFEGGtNGQPIVVRG           :                                                      1qxo(B) : EFGLGFEAGYRKGSQVdEILWSKEDGYTRRTNNLGGFEGGtNGQPIVVRG             ________________________________________________30             9_________323_________________343_________________   1qxo(A) : VkPIPTLYKPLsVDIETHEPYKATVERSDPTALPAAGveAVVATVLAQEI           :                                                      1qxo(B) : VkPIPTLYKPLsVDIETHEPYKATVERSDPTALPAAGveAVVATVLAQEI             9_________323_________________343_________________             __________________________                           1qxo(A) : LEKFSSDNLEELKEAVAKHRDYTKNY                                   :                                                      1qxo(B) : LEKFSSDNLEELKEAVAKHRDYTKNY                                     __________________________

Details

Property   Value  Conformer 1 1qxo(A)  Conformer 2 1qxo(B)  Radius gyration for conformer 1 23.13 A  Radius gyration for conformer 2 23.03 A  EC Number 4.2.3.5   Click here to see the DynDom results or the famliy  Trigger ligands EPS5002  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ALA133  ARG134  ARG337  ARG39  ARG45  ARG48  HIS10  HIS110  SER132   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT