Creatine kinase, M chain
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1u6r(B) : PFGNTHNKYKLNYKSEEEYPDLSKHNNHMAKVLTPDLYKKLRDKETPSGF           :                                                      1u6r(A) : PFGNTHNKYKLNYKSEEEYPDLSKHNNHMAKVLTPDLYKKLRDKETPSGF             __________________________________________________             __________________________________________________   1u6r(B) : TLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGFK           :                                                      1u6r(A) : TLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGFK             __________________________________________________             103_________________________131___________________   1u6r(B) : PTDKHKTDLNHENLKGGDDLDPHYVLSSRVRTGKSIKGYTLPPHCSRGER           :                                                      1u6r(A) : PTDKHKTDLNHENLKGGDDLDPHYVLSSRVRTGKSIKGYTLPPHCSRGER             103_________________________131___________________             _______________________176____________191_________   1u6r(B) : RAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPL           :                                                      1u6r(A) : RAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPL             _______________________176____________191_________             _______________218__223___________237_____________   1u6r(B) : LLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFR           :                                                      1u6r(A) : LLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFR             _______________218__223___________237_____________             _254_______________________________288____________   1u6r(B) : RFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAH           :                                                      1u6r(A) : RFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAH             _254_______________________________288____________             __________________________________________________   1u6r(B) : LSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDISNADRLGSSEVEQVQ           :                                                      1u6r(A) : LSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDISNADRLGSSEVEQVQ             __________________________________________________             ______________________________                       1u6r(B) : LVVDGVKLMVEMEKKLEKGQSIDDMIPAQK                               :                                                      1u6r(A) : LVVDGVKLMVEMEKKLEKGQSIDDMIPAQK                                 ______________________________

Details

Property   Value  Conformer 1 1u6r(B)  Conformer 2 1u6r(A)  Radius gyration for conformer 1 21.01 A  Radius gyration for conformer 2 21.93 A  EC Number 2.7.3.2   Click here to see the DynDom results or the famliy  Trigger ligands IOM1601  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ASN285  CYS282  GLU231  ILE68  LEU200  SER284  THR70  VAL324  VAL71   Residues in extended bending regions contacting ligands ASN285   Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT