Cytochrome P450-cam
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1k2o(A) : ANLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWAVLQESNVPDLVWTRC           :                                                      2frz(B) : *NLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWAVLQESNVPDLVWTRC             __________________________________________________             ___________________________87__________99_________   1k2o(A) : NGGHWIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPTSMDPPEQ           :                                                      2frz(B) : NGGHWIATRGQLIREAYEDYRHFSSECPWIPREAGEAFDFIPTSMDPPEQ             ___________________________87__________99_________             111____118__________131_______________________157_   1k2o(A) : RQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPF           :                                                      2frz(B) : RQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPF             111____118__________131_______________________157_             __________________________________________________   1k2o(A) : PIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPII           :                                                      2frz(B) : PIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPII             __________________________________________________             ________________________________________251_______   1k2o(A) : EQRRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVGGLDTVVNFLS           :                                                      2frz(B) : EQRRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLLGGLDTVVNFLS             ________________________________________251_______             __________________________________________________   1k2o(A) : FSMEFLAKSPEHRQELIERPERIPAACEELLRRFSLVADGRILTSDYEFH           :                                                      2frz(B) : FSMEFLAKSPEHRQELIERPERIPAACEELLRRFSLVADGRILTSDYEFH             __________________________________________________             __________________________________________________   1k2o(A) : GVQLKKGDQILLPQMLSGLDERENAAPMHVDFSRQKVSHTTFGHGSHLCL           :                                                      2frz(B) : GVQLKKGDQILLPQMLSGLDERENAAPMHVDFSRQKVSHTTFGHGSHLCL             __________________________________________________             __________________________________________________   1k2o(A) : GQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALPLVWDP           :                                                      2frz(B) : GQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALPLVWDP             __________________________________________________             ______                                               1k2o(A) : ATTKAV                                                       :                                                      2frz(B) : ATTKAV                                                         ______

Details

Property   Value  Conformer 1 1k2o(A)  Conformer 2 2frz(B)  Radius gyration for conformer 1 21.59 A  Radius gyration for conformer 2 21.24 A  EC Number 1.14.15.1   Click here to see the DynDom results or the famliy  Trigger ligands HEM417  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact No  Spanning ligands Yes  Residues in enzyme contacting ligands  Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG112    Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT