Dephospho-CoA kinase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________43______   1vhl(A) : SLRYIVALTGGIGSGKSTVANAFADLGINVIDADIIARQVVEPGAPALHA           :                                                      1n3b(B) : **RYIVALTGGIGSGKSTVANAFADLGINVIDADIIARQVVEPGAPALHA             __________________________________________43______             ____________________________________87____________   1vhl(A) : IADHFGANMIAADGTLQRRALRERIFANPEEKNWLNALLHPLIQQETQHQ           :                                                      1n3b(B) : IADHFGAN-iAADGTLQRRALRERIFANPEEKNWLNALLHPLIQQETQHQ             ____________________________________87____________             __________________________________________________   1vhl(A) : IQQATSPYVLWVVPLLVENSLYKKANRVLVVDVSPETQLKRTMQRDDVTR           :                                                      1n3b(B) : IQQATSPYVLWVVPLLVENSLYKKANRVLVVDVSPETQLKRT-qRDDVTR             __________________________________________________             __________________________________________________   1vhl(A) : EHVEQILAAQATREARLAVADDVIDNNGAPDAIASDVARLHAHYLQLASQ           :                                                      1n3b(B) : EHVEQILAAQATREARLAVADDVIDNNGAPDAIASDVARLHAHYLQLASQ             __________________________________________________             ________                                             1vhl(A) : FVSQEKPE                                                     :                                                      1n3b(B) : FVSQEKP*                                                       ________

Details

Property   Value  Conformer 1 1vhl(A)  Conformer 2 1n3b(B)  Radius gyration for conformer 1 18.79 A  Radius gyration for conformer 2 18.73 A  EC Number 2.7.1.24   Click here to see the DynDom results or the famliy  Trigger ligands ADP1  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact No  Spanning ligands No  Residues in enzyme contacting ligands ALA178  ARG140  ARG144  ASN175  GLY10  GLY12  GLY14  GLY177  ILE11  LYS15  PRO179  SER13  SER16  THR17   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT