Dihydrodipicolinate reductase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1yl7(C) : ARVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVI           :                                                      1p9l(A) : MRVGVLGAKGKVGTTMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVI             __________________________________________________             __________________________________________________   1yl7(C) : DFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVL           :                                                      1p9l(A) : DFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVL             __________________________________________________             __105_____________________________________________   1yl7(C) : IAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKL           :                                                      1p9l(A) : IAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKL             __105_____________________________________________             __________________________________________________   1yl7(C) : IAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGT           :                                                      1p9l(A) : IAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGT             __________________________________________________             ________211__________________________________        1yl7(C) : EGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH                :                                                      1p9l(A) : EGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH                  ________211__________________________________

Details

Property   Value  Conformer 1 1yl7(C)  Conformer 2 1p9l(A)  Radius gyration for conformer 1 20.35 A  Radius gyration for conformer 2 19.13 A  EC Number 1.3.1.26   Click here to see the DynDom results or the famliy  Trigger ligands PDC302  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ALA192  ASN104  ASP138  GLY142  HIS132  HIS133  LYS136  PHE217  PRO103  SER141  THR143  THR77   Residues in extended bending regions contacting ligands ASN104  PHE217  PRO103   Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT