Dihydrodipicolinate reductase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1yl5(B) : AMARVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEV           :                                                      1yl7(D) : **ARVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEV             __________________________________________________             __________________________________________________   1yl5(B) : VIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTS           :                                                      1yl7(D) : VIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTS             __________________________________________________             _102______________________________________________   1yl5(B) : VLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTA           :                                                      1yl7(D) : VLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTA             _102______________________________________________             __________________________________________________   1yl5(B) : KLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLF           :                                                      1yl7(D) : KLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLF             __________________________________________________             __________211________________________238_______      1yl5(B) : GTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH              :                                                      1yl7(D) : GTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH                __________211________________________238_______

Details

Property   Value  Conformer 1 1yl5(B)  Conformer 2 1yl7(D)  Radius gyration for conformer 1 20 A  Radius gyration for conformer 2 20.27 A  EC Number 1.3.1.26   Click here to see the DynDom results or the famliy  Trigger ligands NAD504  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact No  Spanning ligands Yes  Residues in enzyme contacting ligands ALA102  ALA34  ASN104  ASP33  GLY10  GLY7  GLY75  LEU32  LEU6  LYS11  LYS9  PHE105  PHE217  PHE52  PRO103  PRO55  THR53  THR76  THR77  VAL12  VAL57   Residues in extended bending regions contacting ligands ALA102  ASN104  PHE105  PHE217  PRO103   Residues in extended bending regions making H-bonds or salt-bridges with ligands ALA102  PHE105    Residues in extended bending regions with an H-bond between its main chain and ligands ALA102  PHE105  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT