diphosphate--fructose-6-phosphate 1-phosphotr
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   2f48(B) : TSLFKQERQKYIPKLPNILKKDFNNISLVYGENTEAIQDRQALKEFFKNT           :                                                      2f48(A) : *SLFKQERQKYIPKLPNILKKDFNNISLVYGENTEAIQDRQALKEFFKNT             __________________________________________________             __________________________________________________   2f48(B) : YGLPIISFTEGESSLSFSKALNIGIILSGGPAPGGHNVISGVFDAIKKFN           :                                                      2f48(A) : YGLPIISFTEGESSLSFSKALNIGIILSGGPAPGGHNVISGVFDAIKKFN             __________________________________________________             __________________________________________________   2f48(B) : PNSKLFGFKGGPLGLLENDKIELTESLINSYRNTGGFDIVSSGRTKIETE           :                                                      2f48(A) : PNSKLFGFKGGPLGLLENDKIELTESLINSYRNTGGFDIVSSGRTKIETE             __________________________________________________             __________________________________________________   2f48(B) : EHYNKALFVAKENNLNAIIIIGGDDSNTNAAILAEYFKKNGENIQVIGVP           :                                                      2f48(A) : EHYNKALFVAKENNLNAIIIIGGDDSNTNAAILAEYFKKNGENIQVIGVP             __________________________________________________             _____________________________________________250__   2f48(B) : KTIDADLRNDHIEISFGFDSATKIYSELIGNLCRDAMSTKKYWHFVKLMG           :                                                      2f48(A) : KTIDADLRNDHIEISFGFDSATKIYSELIGNLCRDAMSTKKYWHFVKLMG             _____________________________________________250__             __________________________________________________   2f48(B) : RSASHVALECALKTHPNICIVSEEVLAKKKTLSEIIDEMVSVILKRSLNG           :                                                      2f48(A) : RSASHVALECALKTHPNICIVSEEVLAKKKTLSEIIDEMVSVILKRSLNG             __________________________________________________             _______312________________________________________   2f48(B) : DNFGVVIVPEGLIEFIPEVKSLMLELCDIFDKNEGEFKGLNIEKMKEIFV           :                                                      2f48(A) : DNFGVVIVPEGLIEFIPEVKSLMLELCDIFDKNEGEFKGLNIEKMKEIFV             _______312________________________________________             ____________________________383________394________   2f48(B) : AKLSDYMKGVYLSLPLFIQFELIKSILERDPHGNFNVSRVPTEKLFIEMI           :                                                      2f48(A) : AKLSDYMKGVYLSLPLFIQFELIKSILERDPHGNFNVSRVPTEKLFIEMI             ____________________________383________394________             __________________________________________________   2f48(B) : QSRLNDMKKRGEYKGSFTPVDHFFGYEGRSAFPSNFDSDYCYSLGYNAVV           :                                                      2f48(A) : QSRLNDMKKRGEYKGSFTPVDHFFGYEGRSAFPSNFDSDYCYSLGYNAVV             __________________________________________________             __________________________________________________   2f48(B) : LILNGLTGYMSCIKNLNLKPTDWIAGGVPLTMLMNMEERYGEKKPVIKKA           :                                                      2f48(A) : LILNGLTGYMSCIKNLNLKPTDWIAGGVPLTMLMNMEERYGEKKPVIKKA             __________________________________________________             __________________________________________________   2f48(B) : LVDLEGRPFKEFVKNRDKWALNNLYLYPGPVQYFGSSEIVDEITETLKLE           :                                                      2f48(A) : LVDLEGRPFKEFVKNRDKWALNNLYLYPGPVQYFGSSEIVDEITETLKLE             __________________________________________________             __                                                   2f48(B) : LF                                                           :                                                      2f48(A) : LF                                                             __

Details

Property   Value  Conformer 1 2f48(B)  Conformer 2 2f48(A)  Radius gyration for conformer 1 26.02 A  Radius gyration for conformer 2 24.87 A  EC Number 2.7.1.90   Click here to see the DynDom results or the famliy  Trigger ligands BFP829  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG146  ARG253  ARG431  ASP206  GLU312  GLY252  GLY81  GLY82  ILE205  LYS203  MET251  SER390  THR204  TYR428   Residues in extended bending regions contacting ligands ARG253  GLU312  GLY252  MET251  SER390   Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG253  GLU312  GLY252  SER390    Residues in extended bending regions with an H-bond between its main chain and ligands GLY252  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT