5-enolpyruvylshikimate-3-phosphate synthase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

________________18________________________________   1rf6(C) : MKLKTNIRHLHGIIRVPGDKSISHRSIIFGSLAEGETKVYDILRGEDVLS           :                                                      1rf5(B) : MKLKTNIRHLHGIIRVPGDKSISHRSIIFGSLAEGETKVYDILRGEDVLS             ________________18________________________________             __________________________________________________   1rf6(C) : TMQVFRDLGVEIEDKDGVITVQGVGMAGLKAPQNALNMGNSGTSIRLISG           :                                                      1rf5(B) : TMQVFRDLGVEIEDKDGVITVQGVGMAGLKAPQNALNMGNSGTSIRLISG             __________________________________________________             __________________________________________________   1rf6(C) : VLAGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLK           :                                                      1rf5(B) : VLAGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLK             __________________________________________________             __________________________________________________   1rf6(C) : GTKNLRPIHYELPIASAQVKSALMFAALQAKGESVIIEKEYTRNHTEDML           :                                                      1rf5(B) : GTKNLRPIHYELPIASAQVKSALMFAALQAKGESVIIEKEYTRNHTEDML             __________________________________________________             __________________________229_____________________   1rf6(C) : QQFGGHLSVDGKKITVQGPQKLTGQKVVVPGDISSAAFWLVAGLIAPNSR           :                                                      1rf5(B) : QQFGGHLSVDGKKITVQGPQKLTGQKVVVPGDISSAAFWLVAGLIAPNSR             __________________________229_____________________             __________________________________________________   1rf6(C) : LVLQNVGINETRTGIIDVIRAMGGKLEITEIDPVAKSATLIVESSDLKGT           :                                                      1rf5(B) : LVLQNVGINETRTGIIDVIRAMGGKLEITEIDPVAKSATLIVESSDLKGT             __________________________________________________             __________________________________________________   1rf6(C) : EICGALIPRLIDELPIIALLATQAQGVTVIKDAEELKVKETDRIQVVADA           :                                                      1rf5(B) : EICGALIPRLIDELPIIALLATQAQGVTVIKDAEELKVKETDRIQVVADA             __________________________________________________             __________________________________________________   1rf6(C) : LNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAIAALLVADG           :                                                      1rf5(B) : LNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAIAALLVADG             __________________________________________________             ___________________________                          1rf6(C) : EVELDRAEAINTSYPSFFDDLESLIHG                                  :                                                      1rf5(B) : EVELDRAEAINTSYPSFFDDLESLIHG                                    ___________________________

Details

Property   Value  Conformer 1 1rf6(C)  Conformer 2 1rf5(B)  Radius gyration for conformer 1 21.14 A  Radius gyration for conformer 2 22.68 A  EC Number 2.5.1.19   Click here to see the DynDom results or the famliy  Trigger ligands GPJ1628  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG120  ARG343  ARG385  ASN90  ASP312  GLN168  GLU340  GLY92  HIS384  LYS20  SER91  THR93   Residues in extended bending regions contacting ligands LYS20   Residues in extended bending regions making H-bonds or salt-bridges with ligands LYS20    Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT