farnesyl pyrophosphate synthase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

___________13_____________________________44______   1yhk(A) : MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYF           :                                                      1yhl(A) : MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYF             ___________13_____________________________44______             ___________________________________87_____________   1yhk(A) : RGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDI           :                                                      1yhl(A) : RGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDI             ___________________________________87_____________             _______________________________134________________   1yhk(A) : MDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLK           :                                                      1yhl(A) : MDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLK             _______________________________134________________             __________________________________________________   1yhk(A) : DLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIY           :                                                      1yhl(A) : DLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIY             __________________________________________________             __________________________________________________   1yhk(A) : KRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQD           :                                                      1yhl(A) : KRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQD             __________________________________________________             __________________________________________________   1yhk(A) : DVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDK           :                                                      1yhl(A) : DVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDK             __________________________________________________             __________________________________________________   1yhk(A) : DPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESV           :                                                      1yhl(A) : DPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESV             __________________________________________________             ____________                                         1yhk(A) : AVVWEKTHKR**                                                 :                                                      1yhl(A) : AVVWEKTHKRKK                                                   ____________

Details

Property   Value  Conformer 1 1yhk(A)  Conformer 2 1yhl(A)  Radius gyration for conformer 1 21.66 A  Radius gyration for conformer 2 21.4 A  EC Number 2.5.1.10   Click here to see the DynDom results or the famliy  Trigger ligands DMA1301  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG108  ARG51  GLN91  GLY47  LEU95  LYS264  LYS362  LYS48  PHE246  PHE50  TYR211  TYR49   Residues in extended bending regions contacting ligands GLN91  GLY47  LYS48   Residues in extended bending regions making H-bonds or salt-bridges with ligands GLN91  LYS48    Residues in extended bending regions with an H-bond between its main chain and ligands LYS48  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT