GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTR
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1ecc(B) : CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGL           :                                                      1ecf(B) : CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGL             __________________________________________________             __________________________________________________   1ecc(B) : VSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAH           :                                                      1ecf(B) : VSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAH             __________________________________________________             __________________________________________________   1ecc(B) : NGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEAD           :                                                      1ecf(B) : NGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEAD             __________________________________________________             __________________________________________________   1ecc(B) : NIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDEN           :                                                      1ecf(B) : NIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDEN             __________________________________________________             __________________________________________________   1ecc(B) : RTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSN           :                                                      1ecf(B) : RTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSN             __________________________________________________             __________________________________________________   1ecc(B) : PCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIP           :                                                      1ecf(B) : PCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIP             __________________________________________________             _______________________326_______________344______   1ecc(B) : IPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPGQQLRRKSVRRKL           :                                                      1ecf(B) : IPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPGQQLRRKSVRRKL             _______________________326_______________344______             __________________________________________________   1ecc(B) : NANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIR           :                                                      1ecf(B) : NANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIR             __________________________________________________             __________________________________________________   1ecc(B) : FPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAEN           :                                                      1ecf(B) : FPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAEN             __________________________________________________             __________________________________________________   1ecc(B) : PDIQQFECSVFNGVYVTKDVDQGYLDFLDTLRNDDAKAVQRQ********           :                                                      1ecf(B) : PDIQQFECSVFNGVYVTKDVDQGYLDFLDTLRNDDAKAVQRQNEVENLEM             __________________________________________________

Details

Property   Value  Conformer 1 1ecc(B)  Conformer 2 1ecf(B)  Radius gyration for conformer 1 22.98 A  Radius gyration for conformer 2 23.87 A  EC Number 2.4.2.14   Click here to see the DynDom results or the famliy  Trigger ligands PCP505  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG332  ARG371  ASP366  ASP367  GLU303  GLY372  ILE369  LYS349  PHE334  PRO302  SER368  THR304  THR333  THR373  THR374  TYR258  VAL370   Residues in extended bending regions contacting ligands LYS349   Residues in extended bending regions making H-bonds or salt-bridges with ligands LYS349    Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT