Glycogen synthase 1
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1rzu(B) : MNVLSVSSEIYPLIKTGGLADVVGALPIALEAHGVRTRTLIPGYPAVKAA           :                                                      1rzu(A) : MNVLSVSSEIYPLIKTGGLADVVGALPIALEAHGVRTRTLIPGYPAVKAA             __________________________________________________             __________________________________________________   1rzu(B) : VTDPVKCFEFTDLLGEKADLLEVQHERLDLLILDAPAYYERSGGPYLGQT           :                                                      1rzu(A) : VTDPVKCFEFTDLLGEKADLLEVQHERLDLLILDAPAYYERSGGPYLGQT             __________________________________________________             __________________________________________________   1rzu(B) : GKDYPDNWKRFAALSLAAARIGAGVLPGWRPDMVHAHDWQAAMTPVYMRY           :                                                      1rzu(A) : GKDYPDNWKRFAALSLAAARIGAGVLPGWRPDMVHAHDWQAAMTPVYMRY             __________________________________________________             __________________________________________________   1rzu(B) : AETPEIPSLLTIHNIAFQGQFGANIFSKLALPAHAFGMEGIEYYNDVSFL           :                                                      1rzu(A) : AETPEIPSLLTIHNIAFQGQFGANIFSKLALPAHAFGMEGIEYYNDVSFL             __________________________________________________             ________________________________________243_______   1rzu(B) : KGGLQTATALSTVSPSYAEEILTAEFGMGLEGVIGSRAHVLHGIVNGIDA           :                                                      1rzu(A) : KGGLQTATALSTVSPSYAEEILTAEFGMGLEGVIGSRAHVLHGIVNGIDA             ________________________________________243_______             __________________________________________________   1rzu(B) : DVWNPATDHLIHDNYSAANLKNRALNKKAVAEHFRIDDDGSPLFCVISRL           :                                                      1rzu(A) : DVWNPATDHLIHDNYSAANLKNRALNKKAVAEHFRIDDDGSPLFCVISRL             __________________________________________________             __________________________________________________   1rzu(B) : TWQKGIDLMAEAVDEIVSLGGRLVVLGAGDVALEGALLAAASRHHGRVGV           :                                                      1rzu(A) : TWQKGIDLMAEAVDEIVSLGGRLVVLGAGDVALEGALLAAASRHHGRVGV             __________________________________________________             ____________________373______________________398__   1rzu(B) : AIGYNEPLSHLMQAGCDAIIIPSRFEPCGLTQLYALRYGCIPVVARTGGL           :                                                      1rzu(A) : AIGYNEPLSHLMQAGCDAIIIPSRFEPCGLTQLYALRYGCIPVVARTGGL             ____________________373______________________398__             __________________________________________________   1rzu(B) : ADTVIDANHAALASKAATGVQFSPVTLDGLKQAIRRTVRYYHDPKLWTQM           :                                                      1rzu(A) : ADTVIDANHAALASKAATGVQFSPVTLDGLKQAIRRTVRYYHDPKLWTQM             __________________________________________________             _____458____________________                         1rzu(B) : QKLGMKSDVSWEKSAGLYAALYSQLISK                                 :                                                      1rzu(A) : QKLGMKSDVSWEKSAGLYAALYSQLIS*                                   _____458____________________

Details

Property   Value  Conformer 1 1rzu(B)  Conformer 2 1rzu(A)  Radius gyration for conformer 1 23.91 A  Radius gyration for conformer 2 24.08 A  EC Number 2.4.1.21   Click here to see the DynDom results or the famliy  Trigger ligands ADP2531  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG299  ASN355  GLU356  GLU376  GLY327  GLY353  GLY379  ILE297  LEU326  LEU380  LYS304  SER298  SER359  THR381  TYR354  TYR384   Residues in extended bending regions contacting ligands GLU376  GLY379  LEU380  THR381   Residues in extended bending regions making H-bonds or salt-bridges with ligands THR381    Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT