HEME OXYGENASE-1
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _________________________________45_______________ 
 1ix3(A) : QDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA 
         :                                                    
 1irm(C) : *******************NSEFMRNFQKGQVSREGFKLVMASLYHIYTA 
           _________________________________45_______________ 

           __________________________________________________ 
 1ix3(A) : LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPA 
         :                                                    
 1irm(C) : LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPA 
           __________________________________________________ 

           __________________________139____146_____154______ 
 1ix3(A) : TQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSS 
         :                                                    
 1irm(C) : TQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSS 
           __________________________139____146_____154______ 

           __________________________________________________ 
 1ix3(A) : GEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLN 
         :                                                    
 1irm(C) : GEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLN 
           __________________________________________________ 

           ______________________                             
 1ix3(A) : IELFEELQALLTeFLRQRPASL                             
         :                                                    
 1irm(C) : IELFEELQALLTEEH*******                             
           ______________________                             

Details

  Property   Value
 Conformer 1 1ix3(A)
 Conformer 2 1irm(C)
 Radius gyration for conformer 1 16.63 A
 Radius gyration for conformer 2 16.76 A
 EC Number 1.14.99.3  
Click here to see the DynDom results or the famliy
 Trigger ligands HEM300
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG136  ARG183  ASN210  GLN38  GLU29  GLY139  GLY143  HIS25  LEU138  LEU147  LYS179  LYS18  MET34  PHE207  PHE214  SER142  THR135  TYR134 
 Residues in extended bending regions contacting ligands ARG136  GLY139  GLY143  LEU138  LEU147  SER142 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT