Inositol monophosphatase 2
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   2czh(A) : PWEECFQAAVQLALRAGQIIRKALTEEKdLVTETDHLVEDLIISELRERF           :                                                      2czk(A) : PWEECFQAAVQLALRAGQIIRKALTEE-dLVTETDHLVEDLIISELRERF             __________________________________________________             __________________________________________________   2czh(A) : PSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFA           :                                                      2czk(A) : PSHRFIAE------aKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFA             __________________________________________________             _______________________________________165___171__   2czh(A) : VRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTE           :                                                      2czk(A) : VRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTE             _______________________________________165___171__             __________________194___200_______________________   2czh(A) : IGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYY           :                                                      2czk(A) : IGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYY             __________________194___200_______________________             __________________________________________________   2czh(A) : QFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLI           :                                                      2czk(A) : QFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLI             __________________________________________________             __________                                           2czh(A) : AQAL******                                                   :                                                      2czk(A) : AQALQTINYG                                                     __________

Details

Property   Value  Conformer 1 2czh(A)  Conformer 2 2czk(A)  Radius gyration for conformer 1 17.58 A  Radius gyration for conformer 2 17.73 A  EC Number 3.1.3.25   Click here to see the DynDom results or the famliy  Trigger ligands PO4101  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ASP104  GLN224  ILE174  SER206  SER207   Residues in extended bending regions contacting ligands ILE174   Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT