L-allo-threonine aldolase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

_______6__________________________________________   2fm1(D) : HHMIDLRSDTVTKPTEEMRKAMAQAEVGDDVYGEDPTINELERLAAETFG           :                                                      1lw5(A) : ***IDLRSDTVTKPTEE-rKA-aQAEVGDDVYGEDPTINELERLAAETFG             _______6__________________________________________             __________________________________________________   2fm1(D) : KEAALFVPSGTMGNQVSIMAHTQRGDEVILEADSHIFWYEVGAMAVLSGV           :                                                      1lw5(A) : KEAALFVPSGT-gNQVSI-aHTQRGDEVILEADSHIFWYEVGA-aVLSGV             __________________________________________________             __________________________________________________   2fm1(D) : MPHPVPGKNGAMDPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPL           :                                                      1lw5(A) : -pHPVPGKNGA-dPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPL             __________________________________________________             __________________________________________________   2fm1(D) : ENIKEICTIAKEHGINVHIDGARIFNASIASGVPVKEYAGYADSVMFCLS           :                                                      1lw5(A) : ENIKEICTIAKEHGINVHIDGARIFNASIASGVPVKEYAGYADSV-fCLS             __________________________________________________             __________________________________________________   2fm1(D) : gLCAPVGSVVVGDRDFIERARKARKMLGGGMRQAGVLAAAGIIALTKMVD           :                                                      1lw5(A) : gLCAPVGSVVVGDRDFIERARKARK-lGGG-rQAGVLAAAGIIALTK-vD             __________________________________________________             __254_____________________________________________   2fm1(D) : RLKEDHENARFLALKLKEIGYSVNPEDVKTNMVILRTDNLKVNAHGFIEA           :                                                      1lw5(A) : RLKEDHENARFLALKLKEIGYSVNPEDVKTN-vILRTDNLKVNAHGFIEA             __254_____________________________________________             ____________________________________________         2fm1(D) : LRNSGVLANAVSDTEIRLVTHKDVSRNDIEEALNIFEKLFRKFS                 :                                                      1lw5(A) : LRNSGVLANAVSDTEIRLVTHKDVSRNDIEEALNIFEKLFRKFS                   ____________________________________________

Details

Property   Value  Conformer 1 2fm1(D)  Conformer 2 1lw5(A)  Radius gyration for conformer 1 20.85 A  Radius gyration for conformer 2 21.16 A  EC Number 4.1.2.5   Click here to see the DynDom results or the famliy  Trigger ligands PLG1002  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact No  Spanning ligands No  Residues in enzyme contacting ligands ARG231   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT