L-3-HYDROXYACYL-COA DEHYDROGENASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1f0y(A) : KIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEES           :                                                      1f17(B) : KIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEES             __________________________________________________             __________________________________________________   1f0y(A) : LRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVEN           :                                                      1f17(B) : LRKVAKKKFAENPKAGDECVEKTLSTIATSTDAASVVHSTDLVVEAIVEN             __________________________________________________             __________________________________________________   1f0y(A) : LKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFN           :                                                      1f17(B) : LKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFN             __________________________________________________             ___________________________________199____________   1f0y(A) : PVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLL           :                                                      1f17(B) : PVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLL             ___________________________________199____________             __________________________________________________   1f0y(A) : VPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFI           :                                                      1f17(B) : VPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFI             __________________________________________________             _________________________________________            1f0y(A) : VDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK                    :                                                      1f17(B) : VDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK                      _________________________________________

Details

Property   Value  Conformer 1 1f0y(A)  Conformer 2 1f17(B)  Radius gyration for conformer 1 19.54 A  Radius gyration for conformer 2 20.36 A  EC Number 1.1.1.35   Click here to see the DynDom results or the famliy  Trigger ligands NAD350  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ALA107  ASN135  ASN161  ASP45  GLN46  GLU110  GLY22  GLY23  GLY24  HIS158  ILE108  ILE21  ILE50  LEU25  LYS115  LYS293  MET26  PHE159  SER137  THR257  VAL253   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT