Maltose/maltodextrin import ATP-binding prote
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

____________________________31___36_______________   1q1e(A) : **VQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAG           :                                                      2awn(C) : ASVQLQNVT-------vSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAG             ____________________________31___36_______________             __________________________________________________   1q1e(A) : LETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLK           :                                                      2awn(C) : L-----------------------gVGMVFQSYALYPHLSVAENMSFGLK             __________________________________________________             __________________________________________________   1q1e(A) : LAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAE           :                                                      2awn(C) : LAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAE             __________________________________________________             _____159________170_______________188_____________   1q1e(A) : PSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLA           :                                                      2awn(C) : PSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLA             _____159________170_______________188_____________             __206____213______________________________________   1q1e(A) : DKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAI           :                                                      2awn(C) : DKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAI             __206____213______________________________________             __________________________________________________   1q1e(A) : DQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILE           :                                                      2awn(C) : DQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILE             __________________________________________________             __________________________________________________   1q1e(A) : GEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPER           :                                                      2awn(C) : GEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPER             __________________________________________________             ________________________                             1q1e(A) : CHLFREDGTACRRLHKEPG*****                                     :                                                      2awn(C) : CHLFREDGTACRRLHKEPGVASAS                                       ________________________

Details

Property   Value  Conformer 1 1q1e(A)  Conformer 2 2awn(C)  Radius gyration for conformer 1 25.26 A  Radius gyration for conformer 2 24.39 A  EC Number 3.6.3.19   Click here to see the DynDom results or the famliy  Trigger ligands ADP403  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands No  Residues in enzyme contacting ligands CYS40  GLY39  GLY41  LYS42  SER43  THR44  VAL18   Residues in extended bending regions contacting ligands CYS40  GLY39   Residues in extended bending regions making H-bonds or salt-bridges with ligands GLY39    Residues in extended bending regions with an H-bond between its main chain and ligands GLY39  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT