UDP-N-ACETYLGLUCOSAMINE-1-PHOSPHATE URIDYLTRA
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1hm0(A) : SNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTV           :                                                      1hm9(A) : SNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTV             __________________________________________________             __________________________________________________   1hm0(A) : VGHKAELVEEVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAG           :                                                      1hm9(A) : VGHKAELVEEVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAG             __________________________________________________             _________________________129______________________   1hm0(A) : DTPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIV------vLR           :                                                      1hm9(A) : DTPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLR             _________________________129______________________             _______________169________________________________   1hm0(A) : IVEQKDATDFEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDV           :                                                      1hm9(A) : IVEQKDATDFEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDV             _______________169________________________________             __________________________________________________   1hm0(A) : IGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMRRRINHKHMVNG           :                                                      1hm9(A) : IGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMRRRINHKHMVNG             __________________________________________________             __________________________________________________   1hm0(A) : VSFVNPEATYIDIDVEIAPEVQIEANVILKGQTKIGAETVLTNGTYVVDS           :                                                      1hm9(A) : VSFVNPEATYIDIDVEIAPEVQIEANVILKGQTKIGAETVLTNGTYVVDS             __________________________________________________             __________________________________________________   1hm0(A) : TIGAGAVITNSMIEESSVADGVTVGPYAHIRPNSSLGAQVHIGNFVEVKG           :                                                      1hm9(A) : TIGAGAVITNSMIEESSVADGVTVGPYAHIRPNSSLGAQVHIGNFVEVKG             __________________________________________________             __________________________________________________   1hm0(A) : SSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGDNVF           :                                                      1hm9(A) : SSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGDNVF             __________________________________________________             __________________________________________________   1hm0(A) : VGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDE****           :                                                      1hm9(A) : VGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDEYATR             __________________________________________________             ________                                             1hm0(A) : ********                                                     :                                                      1hm9(A) : LPHHPKNQ                                                       ________

Details

Property   Value  Conformer 1 1hm0(A)  Conformer 2 1hm9(A)  Radius gyration for conformer 1 30.32 A  Radius gyration for conformer 2 29.72 A  EC Number 2.7.7.23   Click here to see the DynDom results or the famliy  Trigger ligands UD11500  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ALA10  ALA100  ALA81  ALA9  ARG15  ASN169  ASN227  ASP102  GLN72  GLN75  GLU154  GLY101  GLY11  GLY139  GLY225  GLY77  ILE198  LEU76  LEU8  LYS22  THR103  THR170  THR199  THR78  TYR138  TYR197   Residues in extended bending regions contacting ligands ASN169  THR170   Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN169  THR170    Residues in extended bending regions with an H-bond between its main chain and ligands ASN169  THR170  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT