PROTEIN (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOT
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1b6r(A) : MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEI           :                                                      1b6s(B) : MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEI             __________________________________________________             _____________________________________________97___   1b6r(A) : ERWPETALTRQLARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLL           :                                                      1b6s(B) : ERWPETALTRELARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLL             _____________________________________________97___             _________________120___________________142________   1b6r(A) : AERSEWPAVFDRLGELAIVKRRTg------QWRLRANETEQLPAECYGEC           :                                                      1b6s(B) : AERSEWPAVFDRLGELAIVKRRTGGYDGRGQWRLRANETEQLPAECYGEC             _________________120___________________142________             153_______________________________________________   1b6r(A) : IVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANA           :                                                      1b6s(B) : IVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANA             153_______________________________________________             __________________________________________________   1b6r(A) : QQQARAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWT           :                                                      1b6s(B) : QQQARAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWT             __________________________________________________             __________________________________________________   1b6r(A) : QNGASISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLV           :                                                      1b6s(B) : QNGASISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLV             __________________________________________________             __________________________________________________   1b6r(A) : HLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWA           :                                                      1b6s(B) : HLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWA             __________________________________________________             _____                                                1b6r(A) : QSKFG                                                        :                                                      1b6s(B) : QSKFG                                                          _____

Details

Property   Value  Conformer 1 1b6r(A)  Conformer 2 1b6s(B)  Radius gyration for conformer 1 20.93 A  Radius gyration for conformer 2 20.62 A  EC Number 4.1.1.21   Click here to see the DynDom results or the famliy  Trigger ligands ADP1200  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ARG129  ARG133  ARG80  ASN237  ASP127  GLN131  GLN154  GLU153  GLU161  GLU238  GLY125  GLY128  GLY155  HIS184  ILE118  ILE156  LYS120  PHE158  PHE228  TYR126   Residues in extended bending regions contacting ligands ARG129  ARG133  ASP127  GLN131  GLN154  GLU153  GLY125  GLY128  GLY155  ILE118  ILE156  LYS120  TYR126   Residues in extended bending regions making H-bonds or salt-bridges with ligands ASP127  GLN131  GLN154  GLU153  GLY125  GLY128  ILE156  LYS120  TYR126    Residues in extended bending regions with an H-bond between its main chain and ligands GLN154  GLY125  GLY128  ILE156  TYR126  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT