PHOSPHOGLYCERATE KINASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1qpg    : SLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVL           :                                                      1fw8(A) : **************************************************             __________________________________________________             __________________________________________________   1qpg    : EHHPRYVVLASHLGQPNGERNEKYSLAPVAKELQSLLGKDVTFLNDCVGP           :                                                      1fw8(A) : *********************SKYSLAPVAKELQSLLGKDVTFLNDCVGP             __________________________________________________             __________________________________________________   1qpg    : EVEAAVKASAPGSVILLENLRYHIEEEGSRKVDGQKVKASKEDVQKFRHE           :                                                      1fw8(A) : EVEAAVKASAPGSVILLENLRYHIEEEGSRKVDGQKVKASKEDVQKFRHE             __________________________________________________             _________________________________________________2   1qpg    : LSSLADVYINDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALEN           :                                                      1fw8(A) : LSSLADVYINDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALEN             _________________________________________________1             02________________________________________________   1qpg    : PTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMAFTFKKVLENTEI           :                                                      1fw8(A) : PTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMAFTFKKVLENTEI             31________________________________________________             __________________________________________________   1qpg    : GDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADANTKTVTD           :                                                      1fw8(A) : GDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADANTKTVTD             __________________________________________________             __________________________________________________   1qpg    : KEGIPAGWQGLDNGPESRKLFAATVAKAKTIVWNGPPGVFEFEKFAAGTK           :                                                      1fw8(A) : KEGIPAGWQGLDNGPESRKLFAATVAKAKTIVWNGPPGVFEFEKFAAGTK             __________________________________________________             ____________________________________389___________   1qpg    : ALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLELL           :                                                      1fw8(A) : ALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLELL             ____________________________________318___________             __________________________________________________   1qpg    : EGKELPGVAFLSEKK***********************************           :                                                      1fw8(A) : EGKELPGVAFLSEKKSLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITS             __________________________________________________             ____________________________________                 1qpg    : ************************************                         :                                                      1fw8(A) : NQRIVAALPTIKYVLEHHPRYVVLASHLGRPNGERN                           ____________________________________

Details

Property   Value  Conformer 1 1qpg( )  Conformer 2 1fw8(A)  Radius gyration for conformer 1 23.87 A  Radius gyration for conformer 2 23.3 A  EC Number 2.7.2.3   Click here to see the DynDom results or the famliy  Trigger ligands 3PG451  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact No  Spanning ligands No  Residues in enzyme contacting ligands ARG121  ARG38  ASN25  ASP23  GLY164  HIS62   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT