Phospho-2-dehydro-3-deoxyheptonate aldolase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1rzm(B) : *****MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDD           :                                                      1vr6(A) : HHHHHMIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDD             __________________________________________________             __________________65______________________________   1rzm(B) : RYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYF           :                                                      1vr6(A) : RYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYF             __________________65______________________________             __________________________________________________   1rzm(B) : TIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEK           :                                                      1vr6(A) : TIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEK             __________________________________________________             __________________________________________________   1rzm(B) : GLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLS           :                                                      1vr6(A) : GLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLS             __________________________________________________             __________________________________________________   1rzm(B) : KAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKA           :                                                      1vr6(A) : KAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKA             __________________________________________________             __________________________________________________   1rzm(B) : TRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGI           :                                                      1vr6(A) : TRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGI             __________________________________________________             ___________________________________________          1rzm(B) : IVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN                  :                                                      1vr6(A) : IVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN                    ___________________________________________

Details

Property   Value  Conformer 1 1rzm(B)  Conformer 2 1vr6(A)  Radius gyration for conformer 1 21.52 A  Radius gyration for conformer 2 23.49 A  EC Number 2.5.1.54   Click here to see the DynDom results or the famliy  Trigger ligands E4P9003 CD9001 CD9009 PEP9002  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands No  Residues in enzyme contacting ligands ALA185  ARG126  ARG133  ARG186  ARG237  ARG247  ASP309  CYS102  GLN182  GLN312  GLU119  GLU164  GLU298  GLY184  HIS115  HIS272  LYS131  LYS207  PRO132  SER308  THR134   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT