RuvB
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1hqc(A) : ALRPKTLDEYIGQERLKQKLRVYLEAAKARKEPLEHLLLFGPPGLGKTTL           :                                                      1ixr(C) : ALRPKTLDEYIGQERLKQKLRVYLEAAKARKEPLEHLLLFGPPGLGKTTL             __________________________________________________             _______________________79_____________________103_   1hqc(A) : AHVIAHELGVNLRVTSGPAIEKPGDLAAILANSLEEGDILFIDEIHRLSR           :                                                      1ixr(C) : AHVIAHELGVNLRVTSGPAIEKPGDLAAILANSLEEGDILFIDEIHRLSR             _______________________79_____________________103_             ___110____117_______________135___________________   1hqc(A) : QAEEHLYPAMEDFVMDIVIGQGPAARTIRLELPRFTLIGATTRPGLITAP           :                                                      1ixr(C) : QAEEHLYPAMEDFVMDIVIGQGPAARTIRLELPRFTLIGATTRPGLITAP             ___110____117_______________135___________________             __________________________________________________   1hqc(A) : LLSRFGIVEHLEYYTPEELAQGVMRDARLLGVRITEEAALEIGRRSRGTM           :                                                      1ixr(C) : LLSRFGIVEHLEYYTPEELAQGVMRDARLLGVRITEEAALEIGRRSRGTM             __________________________________________________             __________________________________________________   1hqc(A) : RVAKRLFRRVRDFAQVAGEEVITRERALEALAALGLDELGLEKRDREILE           :                                                      1ixr(C) : RVAKRLFRRVRDFAQVAGEEVITRERALEALAALGLDELGLEKRDREILE             __________________________________________________             __________________________________________________   1hqc(A) : VLILRFGGGPVGLATLATALSEDPGTLEEVHEPYLIRQGLLKRTPRGRVP           :                                                      1ixr(C) : VLILRFGGGPVGLATLATALSEDPGTLEEVHEPYLIRQGLLKRTPRGRVA             __________________________________________________             ______________                                       1hqc(A) : TELAYRHLGYPPPV                                               :                                                      1ixr(C) : TELARRHL******                                                 ______________

Details

Property   Value  Conformer 1 1hqc(A)  Conformer 2 1ixr(C)  Radius gyration for conformer 1 23.11 A  Radius gyration for conformer 2 23.04 A  EC Number 3.6.1.3   Click here to see the DynDom results or the famliy  Trigger ligands ANP1  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands No  Residues in enzyme contacting ligands ARG205  ARG7  GLY48  GLY50  ILE15  LYS208  LYS51  MET204  THR52  THR53  TYR14   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT