SERYL-tRNA SYNTHETASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

________________________________34________________   1ses(A) : MVDLKRLRQEPEVFHRAIREKGVALDLEALLALDREVQELKKRLQEVQTE           :                                                      1ses(B) : MVDLKRLRQEPEVFHRAIREKGVALDLEALLALDREVQELKKRLQEVQTE             ________________________________34________________             ____________________________________88____________   1ses(A) : RNQVAKRVPKAPPEEKEALIARGKALGEEAKRLEEALREKEARLEALLLQ           :                                                      1ses(B) : RNQVAKRVPKAPPEEKEALIARGKALGEEAKRLEEALREKEARLEALLLQ             ____________________________________88____________             __________________________________________________   1ses(A) : VPLPPWPGAPVGGEEANREIKRVGGPPEFSFPPLDHVALMEKNGWWEPRI           :                                                      1ses(B) : VPLPPWPGAPVGGEEANREIKRVGGPPEFSFPPLDHVALMEKNGWWEPRI             __________________________________________________             __________________________________________________   1ses(A) : SQVSGSRSYALKGDLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFL           :                                                      1ses(B) : SQVSGSRSYALKGDLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFL             __________________________________________________             __________________________________________________   1ses(A) : GTGHFPAYRDQVWAIAETDLYLTGTAEVVLNALHSGEILPYEALPLRYAG           :                                                      1ses(B) : GTGHFPAYRDQVWAIAETDLYLTGTAEVVLNALHSGEILPYEALPLRYAG             __________________________________________________             __________________________________________________   1ses(A) : YAPAFRSEAGSFGKDVRGLMRVHQFHKVEQYVLTEASLEASDRAFQELLE           :                                                      1ses(B) : YAPAFRSEAGSFGKDVRGLMRVHQFHKVEQYVLTEASLEASDRAFQELLE             __________________________________________________             __________________________________________________   1ses(A) : NAEEILRLLELPYRLVEVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCS           :                                                      1ses(B) : NAEEILRLLELPYRLVEVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCS             __________________________________________________             __________________________________________________   1ses(A) : ALLDWQARRANLRYRDPEGRVRYAYTLNNTALATPRILAMLLENHQLQDG           :                                                      1ses(B) : ALLDWQARRANLRYRDPEGRVRYAYTLNNTALATPRILAMLLENHQLQDG             __________________________________________________             _____________________                                1ses(A) : RVRVPQALIPYMGKEVLEPCG                                        :                                                      1ses(B) : RVRVPQALIPYMGKEVLEPCG                                          _____________________

Details

Property   Value  Conformer 1 1ses(A)  Conformer 2 1ses(B)  Radius gyration for conformer 1 27.23 A  Radius gyration for conformer 2 27.06 A  EC Number 6.1.1.11   Click here to see the DynDom results or the famliy  Trigger ligands AMP423  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands No  Residues in enzyme contacting ligands ALA383  ARG256  ARG271  ARG386  GLU258  GLU345  HIS347  LYS277  MET270  PHE275  SER348  THR346  THR380  VAL272   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT