UDP-N-ACETYLMURAMOYL-L-ALANINE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1eeh(A) : ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAV           :                                                      1e0d(A) : ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAV             __________________________________________________             __________________________________________________   1eeh(A) : ERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCR           :                                                      1e0d(A) : ERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCR             __________________________________________________             __________________________________________________   1eeh(A) : EAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE           :                                                      1e0d(A) : EAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE             __________________________________________________             __________________________________________________   1eeh(A) : CELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLR           :                                                      1e0d(A) : CELYVLELSSFQLETTSSLQAVAATILNVTED------fGLQQYRAAKLR             __________________________________________________             __________________________________________________   1eeh(A) : IYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHL------tWLRV           :                                                      1e0d(A) : IYENAKVCVVNADDALTMPI--aDERCVSFGVNMGDYHLNHQQGETWLRV             __________________________________________________             ___________________________________________296____   1eeh(A) : KGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLP           :                                                      1e0d(A) : KGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLP             ___________________________________________296____             __________________________________________________   1eeh(A) : HRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSA           :                                                      1e0d(A) : HRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSA             __________________________________________________             __________________________________________________   1eeh(A) : DFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPR           :                                                      1e0d(A) : DFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPR             __________________________________________________             _____________________________________                1eeh(A) : VQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG                        :                                                      1e0d(A) : VQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG                          _____________________________________

Details

Property   Value  Conformer 1 1eeh(A)  Conformer 2 1e0d(A)  Radius gyration for conformer 1 22.99 A  Radius gyration for conformer 2 23.93 A  EC Number 6.3.2.9   Click here to see the DynDom results or the famliy  Trigger ligands UMA450  Trigger ligands in which conformation Conformation  1  Conformaton with trigger ligands is compact Yes  Spanning ligands No  Residues in enzyme contacting ligands ARG37  ASN138  ASP35  GLN162  GLY12  GLY137  GLY14  GLY140  GLY73  HIS183  ILE11  LEU15  PHE161  PRO142  PRO72  SER159  SER71  THR16  THR36   Residues in extended bending regions contacting ligands Null  Residues in extended bending regions making H-bonds or salt-bridges with ligands Null   Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT