PROTEIN (URIDYLMONOPHOSPHATE/CYTIDYLMONOPHOSP
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1uke    : *EKSKPNVVFVLGGPGSGKGTQCANIVRDFGWVHLSAGDLLRQEQQSGSK 
         :                                                    
 1qf9(A) : MEKSKPNVVFVLGGPGSGKGTQCANIVRDFGWVHLSAGDLLRQEQQSGSK 
           __________________________________________________ 

           __________________________________________________ 
 1uke    : DGEMIATMIKNGEIVPSIVTVKLLKNAIDANQGKNFLVDGFPRNEENNNS 
         :                                                    
 1qf9(A) : DGEMIATMIKNGEIVPSIVTVKLLKNAIDANQGKNFLVDGFPRNEENNNS 
           __________________________________________________ 

           _____________________124__________________145_____ 
 1uke    : WEENMKDFVDTKFVLFFDCPEEVMTQRLLKRGESSGRSDDNIESIKKRFN 
         :                                                    
 1qf9(A) : WEENMKDFVDTKFVLFFDCPEEVMTQRLLKRGESSGRSDDNIESIKKRFN 
           _____________________124__________________145_____ 

           ____________________________________________       
 1uke    : TFNVQTKLVIDHYNKFDKVKIIPANRDVNEVYNDVENLFKSMGF       
         :                                                    
 1qf9(A) : TFNVQTKLVIDHYNKFDKVKIIPANRDVNEVYNDVENLFKSMGF       
           ____________________________________________       

Details

  Property   Value
 Conformer 1 1uke( )
 Conformer 2 1qf9(A)
 Radius gyration for conformer 1 16.32 A
 Radius gyration for conformer 2 16.19 A
 EC Number 2.7.4.14  
Click here to see the DynDom results or the famliy
 Trigger ligands C5P196
ADP195
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA37  ARG127  ARG131  ARG137  ARG148  ARG176  ARG42  ARG93  ASN97  ASP139  ASP177  GLU63  GLY16  GLY18  GLY20  GLY38  GLY90  ILE59  ILE64  LEU41  LYS19  MET58  PHE91  SER17  THR21  VAL178  VAL65 
 Residues in extended bending regions contacting ligands ARG127  ARG148 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG148 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT