Bromodomain-Containing Protein 4

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-82   PHE-83  8.2 8.3 2.6 -2.1 134.0 132.2 12.8
 PHE-83   GLN-84  6.7 6.7 0.3 -2.1 118.1 119.1 10.4
 GLN-84   GLN-85  10.3 10.3 4.3 -2.9 165.4 165.0 -63.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-102   THR-103  5.0 4.9 0.1 1.3 88.0 90.0 -275.2
 THR-103   PRO-104  3.6 3.7 -5.1 -1.7 43.7 46.5 329.4
 PRO-104   MET-105  0.7 0.7 -1.1 -1.5 76.4 74.1 14.7
 MET-105   ASP-106  3.7 3.8 0.9 -4.5 142.4 143.5 66.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PHE-133   THR-134  3.9 3.9 1.1 3.9 104.6 103.8 -41.8
 THR-134   ASN-135  6.0 6.0 -3.2 1.3 64.1 64.7 41.9
 ASN-135   CYS-136  4.0 3.9 0.3 0.6 47.0 46.7 12.6
 CYS-136   TYR-137  3.2 3.2 -2.1 2.5 118.4 118.2 -29.0
 TYR-137   ILE-138  6.2 6.2 -2.7 -4.3 55.3 55.2 83.8
 ILE-138   TYR-139  8.3 8.3 1.5 3.6 93.8 97.8 -104.9
 TYR-139   ASN-140  8.2 8.2 -2.1 1.4 145.1 143.0 378.8
 ASN-140   LYS-141  8.7 8.8 -15.0 29.2 126.5 127.6 128.9
 LYS-141   PRO-142  10.6 11.0 -4.2 -2.1 146.8 140.9 -356.3
 PRO-142   GLY-143  9.7 10.1 -2.4 1.5 129.9 135.4 25.3
 GLY-143   ASP-144  8.2 8.7 6.0 -1.7 112.1 106.8 22.1
 ASP-144   ASP-145  8.4 8.6 -0.8 -0.4 102.8 105.8 -118.2
 ASP-145   ILE-146  7.1 7.1 1.2 3.0 129.4 129.7 -5.6
 ILE-146   VAL-147  5.3 5.3 -0.8 -1.7 95.4 94.4 -62.6
 VAL-147   LEU-148  3.7 3.8 1.3 -1.5 36.5 37.0 -19.3
 LEU-148   MET-149  2.4 2.4 1.5 -0.5 103.0 102.3 45.2
 MET-149   ALA-150  2.8 2.8 2.0 -2.5 121.4 121.2 -48.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees