Basic Fibroblast Growth Factor Receptor 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  MET-535   LYS-536  5.5 6.2 -17.3 27.1 95.1 94.4 -8.3  LYS-536   MET-537  7.6 8.6 -17.3 14.4 147.6 142.6 20.5  MET-537   ILE-538  6.4 7.5 -14.0 16.6 89.6 86.7 10.5 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ILE-544   ILE-545  3.3 3.1 25.2 -16.0 40.5 39.7 19.1  ILE-545   ASN-546  1.8 1.4 -15.4 -0.6 72.8 66.7 47.3  ASN-546   LEU-547  2.2 2.6 7.8 9.6 72.0 72.7 69.0 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ILE-560   VAL-561  9.6 9.6 3.9 -0.1 71.6 69.9 1.8  VAL-561   GLU-562  5.9 5.9 2.0 -0.2 141.1 140.3 -14.8  GLU-562   TYR-563  2.6 2.6 -0.5 -20.0 61.2 63.1 82.5 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ILE-639   ALA-640  6.9 6.4 4.3 21.8 82.9 80.5 19.7  ALA-640   ASP-641  7.1 6.7 -23.1 -4.1 57.9 36.0 81.7  ASP-641   PHE-642  9.7 8.3 -35.0 5.4 7.0 13.8 174.9  PHE-642   GLY-643  8.7 6.5 -27.6 -44.9 65.6 56.3 153.0  GLY-643   LEU-644  12.2 7.3 18.9 42.0 150.6 94.6 -193.3  PRO-663   VAL-664  20.7 21.2 -36.1 -15.7 53.1 40.4 193.4  VAL-664   LYS-665  23.2 23.5 10.5 -5.3 80.6 85.8 -10.6 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees